UBE2C

UBE2C

A gene on chromosome 20q13.12 that encodes a member of the E2 ubiquitin-conjugating enzyme family required for post-replicative DNA damage repair. UBE2C is required for the destruction of mitotic cyclins and for cell cycle progression.
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The resulting analysis identified 18 genes - some such as AURKA, UBE2C, TPX2, FAM83D, ZNF217, SALL4 and MMP9 have been previously known to potentially cause cancer.
Two of the E2 enzymes with a role in cancer are UbcH10 (also known as UBE2C or UBC4) and UBE2S (also called E2-EPF), both of which work with E3 ligase APC/C (Anaphase Promoting Complex/Cyclosome) in the regulation of the cell cycle.
The qPCR primers and hydrolysis probes for the genes CALM2 [calmodulin 2 (phosphorylase kinase, delta)], CHPT1 (choline phosphotransferase 1), CXCL13 [chemokine (C-X-Cmotif) ligand 13], ERBB2 [v-erbb2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)], ESR1 (estrogen receptor 1), IGKC (immunoglobulin kappa constant), MLPH (melanophilin), MMP1 [matrix metallopeptidase 1 (interstitial collagenase)], OAZ1 (ornithine decarboxylase antizyme 1), PGR (progesterone receptor), RAC-GAP1 (Rac GTPase activating protein 1), RPL37A, TOP2A [topoisomerase (DNA) II alpha 170kDa], and UBE2C (ubiquitin-conjugating enzyme E2C) were identified with Primer Express[TM] software (Applied Biosystems) according to the manufacturer's instructions.
5 2 93002 1651_at ubiquitin-conjugating enzyme UBE2C 2.