Tzanck test


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Tzanck test

(tsahnk),
the examination of fluid from a bullous lesion for Tzanck cells (altered epithelial cells, rounded and devoid of intercellular attachments). The periphery of these cells is basophilic and the nucleus is spheric and enlarged with prominent nucleoli; they are characteristic of lesions due to varicella, herpes zoster, herpes simplex, and pemphigus vulgaris.

Tzanck test

[tsangk]
Etymology: Arnault Tzanck, Russian dermatologist in France, 1886-1954
a microscopic examination of cellular material from skin lesions to help diagnose certain vesicular diseases. The tissue is scraped from the base of a vesicle, placed on a slide, and stained with Wright's or Giemsa's stain. Multinucleated giant cells are diagnostic of herpesvirus or varicella. Typical pemphigus and other cells also can be identified.

Tzanck test

(tsănk)
[Arnault Tzanck, Russ. dermatologist in Paris, 1886–1954]
The examination of cells scraped from the lower surface of a vesicle to determine the underlying disease (e.g., infection with a herpesvirus).

Tzanck,

Arnault, Russian dermatologist, 1886-1954.
Tzanck cells - acantholytic epithelial cells seen in the Tzanck test.
Tzanck test - the examination of fluid from a bullous lesion for Tzanck cells.
References in periodicals archive ?
Because the classical viral culture usually requires several days, cytologic methods such as the Tzanck test are used to support the clinical diagnosis in an early stage, although the Tzanck test cannot distinguish between VZV and HSV infections.
The percentage of positivity of Tzanck test for HSV has been reported between 53.
Tzanck test showed multi-nucleated giant cell in all patients.
The diagnosis is confirmed by viral culture, direct immunofluorescence, polymerase chain reaction (PCR) or by skin cytology using Tzanck test.
Besides the diagnosis of SOIJA, in bullous ENL other bullous disorders like pemphigus vulgaris, bullous drug eruption or bullous pemphigoid should be ruled out when there is involvement of oral mucosa and acantholytic cells are found on a Tzanck test.
35) The Tzanck test (direct microscopic examination of skin scrapings) has fallen out of favor, and PCR is now the gold standard.
The diagnosis of the KVE on pre-existing irritant contact dermatitis was supported by Tzanck test in addition to histologic evaluation, and confirmed by the detection of anti HSV-1 IgM.
Cellular detection methods, including Tzanck test and Pap smear, are not recommended for HSV detection because of their low sensitivity, she said.
Congenital Langerhans cell histiocytosis: the utility of the Tzanck test as a diagnostic screening tool.
3), fasting blood sugar on two occasions 308 mg/dl and 300 mg/dl, Tzanck test from the ulceration did not reveal any acantholytic cells, Culture on Sabouraud's media grew C.
Investigations such as hemogram, skin biopsy, KOH examination, Tzanck test, Gram's smear, Wood's lamp examination and urine examination were carried out as and when required.
Light microscopy can be used to do a Tzanck test, which looks for multinucleated giant cells in blister fluid.