Tula Virus

A distinct regional member of the Hantavirus group isolated from a rodent reservoir, the European common vole (Microtus arvalis), found in Europe, Scandinavia and Western Russia
References in periodicals archive ?
Extensive host sharing of central European Tula virus.
DOBV SK, Dobrava virus-Aa, strain Slovakia; DOBV SLO, Dobrava virus-Af, strain Slovenia; PUUV, Puumala virus, strain Vranica; TULV, Tula virus, strain Moravia; HNTV, Hantaan virus, strain 76-118; SEOV, Seoul virus, strain 80-39; FLU, influenza; YFV, yellow fever virus; TBEV, tick-borne encephalitis virus; DNV, dengue virus types 1-4; RVFV, Rift Valley fevervirus; MBV, Marburg virus; EBOV, Ebola virus; VEEV, Venezuelan equine encephalitis virus; ADV, adenovirus; VAC, vaccinia virus.
Antibodies to PUUV, Tula virus (TULV), and Seoul virus (SEOV) have been found in rodent populations in the Netherlands, and TULV has been isolated from common voles (Microtus arvalis) (5,6).
These findings underline the current problem of identifying hantavirus reservoirs (14) as was recently also observed for European Tula virus (15) .
At least 5 hantavirus species are known to circulate in Europe: Dobrava-Belgrade virus, Puumala virus (PUUV), Seoul virus, Saarema virus, and Tula virus (TULV).
agrestis voles, among the most numerous mammals in mainland Britain, have not been shown to be primary carriers of a specific hantavirus, although recent studies suggest that they might be involved in the maintenance of Tula virus in Germany (10).
Although 3 hantaviruses, Puumala virus (PUUV), Dobrava-Belgrade virus, and Tula virus circulate in rodent hosts in Germany and can infect humans (6-8), most hantavirus infections in humans are caused by PUUV.
Longitudinal study in Germany: occurence of Tula virus in Microtus arvalis and Microtus agrestis.
Cao Bang virus (CBNV TC-3), EF543526; Hantaan virus (HTNV 76-118), NC_005219; Seoul virus (SEOV 80-39), NC_005237; Soochong virus (SOOV SC-1), AY675353; Dobrava virus (DOBV Greece), NC_005234; Puumala virus (PUUV Sotkamo), NC_005223; Prospect Hill virus (PHV PH-1), X55129; Tula virus (TULV Moravia 5302v), NC_005228; Sin Nombre virus (SNV NMH10), NC_005215, and Andes virus (ANDV Chile-9717869), NC_003467.
At least 3 different pathogenic hantavirus species have been detected in Europe: Dobrava-Belgrade virus (DOBV), Tula virus, and Puumala virus (PUUV) (1-3).
Hantaan virus (HTNV) shares a multimillennium relationship with the striped field mouse (Apodemus agrarius), Dobrava virus (DOBV) with the yellow-necked field mouse (Apodemus flavicollis), Seoul virus (SEOV) with the Norway rat (Rattus norvegicus), Thailand virus (THAIV) with the bandicoot rat (Bandicota indica), Puumala virus (PUUV) with the bank vole (Myodes glareolus, formerly Clethrionomys glareolus), Tula virus (TULV) with the European common vole (Microtus arvalis), Prospect Hill virus (PHV) with the meadow vole (M.
Additionally, Tula virus RNA was amplified from lung tissues of a European pine vole (Pitymys subterraneus) in Serbia (10).