trypsin inhibitor

(redirected from Trypsin inhibitors)

tryp·sin in·hib·i·tor

1. a peptide formed from trypsinogen through hydrolysis under the catalytic influence of enteropeptidase, with trypsin also produced as a result; so called because the peptide masks or inhibits the active site of the trypsin molecule;
2. one of the polypeptides, from various sources (for example, human and bovine colostrum, soybeans, egg white), that inhibit the action of trypsin. Compare: Bowman-Birk inhibitor.

trypsin inhibitor

one of a group of peptides, present in such varied sources as soybeans, egg white, and human colostrum, that mask or inhibit the active site of the trypsin molecule. Also called kunitz inhibitor.

trypsin

a proteolytic enzyme formed in the intestine by the cleavage of trypsinogen by enterokinase. Trypsinogen enters the intestine as part of the intestinal juice. It is an endopeptidase that hydrolyzes peptides of arginine or lysine.

trypsin fecal tests
see fecal trypsin.
feline trypsin-like immunoreactivity (fTLI)
see trypsin-like immunoreactivity (below).
trypsin inhibitor
small protein synthesized in the exocrine pancreas which prevents conversion of trypsinogen to trypsin, so protecting itself against trypsin digestion. Pancreatic trypsin inhibitor competitively binds to the active site of trypsin and inactivates it at a very low concentration. The binding is amongst the strongest noncovalent associations, but only a fraction of the potential trypsin is so inhibited.
trypsin-like immunoreactivity (TLI)
serum proteins, particularly trypsinogen, react immunologically as trypsin and a normal level is dependent upon a normally functional pancreas. This is used in the diagnosis of exocrine pancreatic insufficiency.
References in periodicals archive ?
Trypsin inhibitors (TI) may actually cause an increase in the secretion of digestive enzymes, including trypsin, chymotrypsin and elastase by inducing hypertrophy and hyperplasia of the pancreas in animals, particularly monogastrics, and can depress their growth (Liener et al.
However, soybean meal contains several antinutritional factors, in particular, trypsin inhibitors and some of oligosaccharides which depress growth rate and decrease efficiency of nutrient utilization when fed to swine (Anderson et al.
Therefore, the total TI activities of the samples will be the sum of the trypsin inhibitor activities of both the tannin and the proteinaceous trypsin inhibitors.
5 RSBM, raw soybean meal; SBM, soybean meal; DM, dry matter; CF, crude fibre; CP, crude protein; EE, ether extract; AME, calculated value of gross energy; KOH, protein solubility; TI, trypsin inhibitors; TIU, trypsin inhibitors units; UA, urease activities.
Anti-nutritional factors in soybean meal, including trypsin inhibitors, insoluble carbohydrates, saponins and proteins, which cause an immune response, have been cited as causes for this common effect.
Synergistic enhancement of the antifungal activity of wheat and barley thionins by radish and oilseed rape 2S albumins and by barley trypsin inhibitors.
In the previous studies, chickpea whole seeds have been found to contain 9 to 31 mg/g (dry weight basis) of trypsin inhibitors [7], 740-763 mg/100 g (dry weight basis) of tannin and 138-171 mg/100 g of phytate (dry weight basis) [8].
Among the various trypsin inhibitors tested, the natural airway inhibitor, secretory leukoprotease inhibitor (SLPI), which is secreted from non-ciliated secretory airway Clara and goblet cells, (36),(37) and is found in bronchoalveolar lavage fluid and nasal and salivary secretion, efficiently suppresses proteolytic activation of IAV HA and viral multiplication.
Detection of trypsin inhibitors, chymotrypsin inhibitors and elastase inhibitors in the cladodes.