NTRK3

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NTRK3

A gene on chromosome 15q25 that encodes TrkC receptor, a tyrosine-protein kinase receptor activated by neurotrophin-3 (NT-3) and is found on proprioceptive sensory neurons; its substrates include SHC1, PI-3 kinase and PLCG1.
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Both TrkA and TrkC receptors express immunoreactivity in the bovine follicular cells (Munoz et al.
In vitro analysis of human neuroblastoma cell lines indicated that both decreasing NT-3 expression and culturing in the presence of an antibody that blocked NT-3 binding to TrkC triggered the cells to undergo apoptosis.
The product is a new orally available, selective tyrosine kinase inhibitor and is designed as a targeted therapeutic candidate to treat patients with cancers that harbour activating alterations to TrkA, TrkB, TrkC, ROS1 or ALK.
Correlations among neural cell adhesion molecule, nerve growth factor, and its receptors, TrkA, TrkB, TrkC, and p75, in perineural invasion by basal cell and cutaneous squamous cell carcinomas.
Entrectinib is designed as a targeted therapeutic candidate to treat patients with cancers that harbour activating alterations to TrkA, TrkB, TrkC, ROS1 or ALK.
During the second stage, it will also offer a preliminary assessment of anti-tumour activity in cancer patients preselected to have an alteration in genes affecting the TRKA, TRKB or TRKC proteins.
Histopathological and molecular prognostic markers in medulloblastoma: c-myc, N-myc, TrkC, and anaplasia.