NTRK2

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NTRK2

A gene on chromosome 9q22.1 that encodes neurotrophic tyrosine kinase receptor type 2 (TrkB), which has the highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, long-term potentiation and apoptosis of CNS neurons. TrkB is activated by BDNF, but also by NT-3 and NT-4.
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Protein levels of BDNF and TrkB in the 100 mg/kg GLe-treated group were not significantly different from those in the vehicle-treated group [Figure 4].
KEYWORDS: Physical activity, Morphine, Abstinence syndrome, Psychological dependency, BDNF, TrkB Hippocampus, Rat.
Glia- and neuron-specific functions of TrkB signalling during retinal degeneration and regeneration.
7,8-Dihydroxyflavone, a TrkB agonist, attenuates behavioral abnormalities and neurotoxicity in mice after administration of methamphetamine.
Selective inhibition of kindling development by intraventricular administration of TrkB receptor body.
Earlier research in epilepsy flagged a receptor in the nervous system called TrkB as a key player in transforming the brain from normal to epileptic.
Se ha observado una represion significativa de la transcripcion del gen de TrkB dependiente de T3, en cerebro de rata hipotiroidea de 15 dias postnatales.
TrkA mediates the biological response of NGF, while BDNF and NT-4/5 are the preferred ligands for TrkB (Ohira1 and Hayashi, 2009).
The interaction of TrkB with BDNF results in dimerization and autophosphorylation of the receptor (Minichiello 2009; Reichardt 2006).
Neurotrophins show their effects through low-affinity p75 neurotrophin receptor (p75NTR) and high-affinity tyrosine kinase (Trk) receptors (TrkA, TrkB and TrkC), which belong to the TNF receptor superfamily (11).
TrkB Low levels of this protein, which works with BDNF in the brain, have been linked to suicide.