NTRK1

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NTRK1

A gene on chromosome 1q21-q22 that encodes neurotrophic tyrosine kinase receptor type 1 (TrkA) which, after neurotrophin binding, phosphorylates itself (autophosphorylates) and members of the MAPK pathway. TrkA potently binds nerve growth factor (NGF) and is involved in differentiation and survival of neurons and in control of gene expression of enzymes involved in neurotransmitter synthesis. It is involved in cell differentiation and may play a role in specifying sensory neuron subtypes.

Molecular pathology
NTRK1 mutations are associated with congenital insensitivity to pain with anhidrosis, self-mutilating behaviour, mental retardation and cancer.
References in periodicals archive ?
2000) Nerve growth factor (NGF) influences differentiation and proliferation of myogenic cells in vitro via TrKA.
Molecular basis of congenital insensitivity to pain with anhidrosis (CIPA): mutations and polymorphisms in TRKA (NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor.
NGF este eliberat in periferie, se leaga specific de receptorii TrkA de la nivelul terminatiilor nervoase nociceptive si, pe cale axonala retrograda, ajunge la ganglionul radacinii dorsale, unde expresia genelor in neuropeptide si receptori moleculari este crescuta.
Sin embargo, se ha descrito que la union de neurotrofinas al receptor p75 en ausencia de TrkA puede inducir la apoptosis mas que evitarla, por hidrolisis de esfingomielina y activacion del receptor NMDA (N-metil-D-aspartato) en el hipocampo (22).
Keratokonuslu kornealar NGF-reseptoru TrkA (TrkA(NGFR) disavurumunun tumuyle yoklugu ile NGF ve p75(NTR)'in disavurumunun dusuklugu ile karakterizedir.
GBR 900 including the exclusive target license to commercialize monoclonal antibodies against TrkA receptor for pain from Lay Line Genomics, an Italian based Company.
Choline pivaloyl ester enhances brain expression of both nerve growth factor and high-affinity receptor TrkA, and reverses memory and cognitive deficits, in rats with excitotoxic lesion of nucleus basalis magnocellularis.
Proximagen will acquire certain of Cambridge Biotechnology's programmes, as well as two clinical stage programmes (5-HT2c agonist programme and the cognition programme, 5-HT6), and a number of pre-clinical stage programmes including VAP-1 and TrkA from Biovitrum.
When TRKA gets turned on by a nerve growth factor (NGF) ligand, the AML cells start to rapidly grow," the expert added.
Tseng et al (10) investigated the molecular mechanisms governed by the HAM and suggested that the NGF abundantly present in HAM stromal matrix and TrkA (NGF high affinity receptor) expressed by the basal cells of the limbal epithelium, could sustain the anti-apoptotic survival of the cells.