Printer Friendly
Dictionary, Encyclopedia and Thesaurus - The Free Dictionary
3,903,999,284 visitors served.
forum Join the Word of the Day Mailing List For webmasters
?
Dictionary/
thesaurus
Medical
dictionary
Legal
dictionary
Financial
dictionary
Acronyms
 
Idioms
Encyclopedia
Wikipedia
encyclopedia
?

Trinucleotide repeat expansion

   Also found in: Encyclopedia, Wikipedia 0.02 sec.
Trinucleotide repeat expansion
A sequence of three nucleotides that is repeated too many times in a section of a gene.
Mentioned in: Myotonic Dystrophy


Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content.
?Page tools
Printer friendly
Cite / link
Feedback
Add definition
Mentioned in?  References in periodicals archive?   Medical browser?   Full browser?
 
An example is fragile X syndrome, which is the result of a trinucleotide repeat expansion in one region of the genome that can result in autistic behavior, intellectual impairment, and seizures.
Massimo Pandolfo's Houston laboratory identified the mutation in FRDA, a homozygous GAA trinucleotide repeat expansion on chromosome 9, and established that a protein named frataxin was deficient.
Since many forms of ataxia are caused by trinucleotide repeat expansions we spent a long time developing a method (called the RAPID cloning method) that selectively identifies these genetic changes.
 
 
 
Medical Dictionary
?

Terms of Use | Privacy policy | Feedback | Advertise with Us | Copyright © 2012 Farlex, Inc.
Disclaimer
All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.