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Related to Trental: pentoxifylline


Apo-Pentoxiphylline, Neotren (UK), Pentoxil, Pentoxiphylline (CA), Pentoxiphylline SR (CA), Trental

Pharmacologic class: Hemorrheologic, xanthine derivative

Therapeutic class: Hematologic agent

Pregnancy risk category C


Unknown. Thought to enhance blood flow to the circulatory system by increasing vasoconstriction and oxygen concentrations.


Tablets (controlled-release, extended-release): 400 mg

Indications and dosages

Intermittent claudication

Adults: 400 mg t.i.d. If adverse reactions occur, decrease to 400 mg b.i.d.

Dosage adjustment

• Renal impairment

Off-label uses

• Diabetic angiopathies and neuropathies
• Transient ischemic attacks
• Severe idiopathic recurrent aphthous stomatitis
• Raynaud's phenomenon


• Hypersensitivity to drug or methylxanthines (such as caffeine, theophylline, theobromine)
• Recent cerebral or retinal hemorrhage


Use cautiously in:
• patients at risk for bleeding
• pregnant or breastfeeding patients
• children (safety not established).


• Give with meals to minimize GI distress.
• Make sure patient swallows tablets whole without crushing, breaking, or chewing.

Adverse reactions

CNS: agitation, dizziness, drowsiness, headache, insomnia, nervousness, tremor, anxiety, confusion, malaise

CV: angina, edema, hypotension, arrhythmias

EENT: blurred vision, epistaxis, laryngitis, nasal congestion, sore throat

GI: nausea, vomiting, constipation, diarrhea, abdominal discomfort, belching, bloating, dyspepsia, flatus, cholecystitis, dry mouth, excessive salivation, anorexia

Hematologic: leukopenia

Respiratory: dyspnea

Skin: rash, urticaria, pruritus, brittle fingernails, flushing, angioedema

Other: bad taste, weight changes, thirst, flulike symptoms, lymphadenopathy


Drug-drug.Anticoagulants, nonsteroidal anti-inflammatory drugs (NSAIDs): increased risk of bleeding Antihypertensives: additive hypotension

Theobromide, theophylline: increased risk of theophylline toxicity

Drug-herbs.Anise, arnica, asafetida, chamomile, clove, dong quai, fenugreek, feverfew, garlic, ginger, ginkgo, ginseng, licorice: increased risk of bleeding

Drug-behaviors.Smoking: decreased pentoxifylline efficacy

Patient monitoring

• Monitor vital signs and cardiovascular status. Watch for arrhythmias, angina, edema, and hypotension.
• Frequently monitor prothrombin time and International Normalized Ratio in patients receiving warfarin concurrently.
• Assess theophylline level in patients receiving theophylline-containing drugs concurrently.

Patient teaching

• Instruct patient to take with meals and to swallow tablets whole without crushing, breaking, or chewing.

Inform patient that drug can cause serious adverse effects. Instruct him to immediately report chest pain, swelling, and flulike symptoms.
• Tell patient smoking may make drug less effective and that many over-the-counter preparations (including aspirin, NSAIDs, and herbs) increase risk of bleeding.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, herbs, and behaviors mentioned above.


A trademark for the drug pentoxifylline.


a trademark for an oral hemorrheological drug (pentoxifylline).


Pentoxifylline, see there.


A brand name for OXPENTIFYLLINE (pentoxifylline).
References in periodicals archive ?
Eugene Melnyk, Chairman of the Board, stated that, "We are excited by the approval of our generic version of Trental by the FDA.
Hoechst-Roussel also shipped supplies of Altace (ramipril), an antihypertensive; Lasix (furosemide), a diuretic; DiaBeta (glyburide), an oral anti-diabetic; and Trental (pentoxyfilline), a treatment for improving blood circulation.
The continuing success of Tiazac(R); the expected success of Biovail's generic controlled release versions of Cardizem SR, Cardizem CD, Trental and Verelan currently pending FDA approval; and the potential of the company's additional eight products in various stages of development, will all contribute to the ongoing success of the company.
and Trental (pentoxyfylline), a treatment for improving blood circulation.
In Life Sciences, sales and earnings increased over those of last year due to strong sales of DiaBeta (glyburide), an oral anti-diabetic, Trental (pentoxifylline), which improves blood flow in the arteries, and Claforan (cefotaxime sodium), an antibiotic, and the launch of two new products, Altace (ramipril) for hypertension and Prokine (sargramostim), used in bone marrow transplants.
Trental sales in North America currently approximate $200 million while sales outside North America represent an additional $150 million.
John Foxe makes the axis of dispute particularly clear when he explains that the "Church of Rome" does not understand the meaning of the Crucifixion, "as may sensibly appeare by their doctrine and institutes, by their auricular confession and satisfaction for sinnes, by their dayly sacrifices, propitiatory Masses, trentals, and Purgatory, by merites of supererogation, inuocation of Saintes, the popes pardon, & dispensations.