traumatic axonal injury

traumatic axonal injury

A post-traumatic form of diffuse brain injury which affects the white matter, and is divided into three grades by histology.

Traumatic axonal injury
Grade 1: Abnormalities are identified by histology only.
Grade 2: Widely distributed axonal damage, plus focal lesion in the corpus callosum.
Grade 3: Diffuse axonal damage, plus focal lesions in the corpus callosum and the brainstem.

Diagnosis
Immunocytochemistry for amyloid precursor protein A-beta-PP, which can be identified in all patients who survive 3+ hours after traumatic head injury. A-beta-PP can also be seen in infarction, hypoglycaemia, and HIV infection. Long-standing lesions can be identified by CD68, a marker of microglial activation.
References in periodicals archive ?
One-year follow-up of patients after traumatic axonal injury has shown that fatigued patients had subjective experience of significantly higher cognitive dysfunction and a lower quality of life than shown on the application scales [12].
found that injecting MDL28170 before TBI alleviated traumatic axonal injury, which proved potential efficacy of MDL28170 for TBI.
Data reported at the annual meeting of the American Academy of Neurology show that 43% of a cohort of 40 symptomatic NFL retirees had abnormal results on diffusion tensor MRI and 30% had evidence of traumatic axonal injury on conventional MRI.
Omega-3 fatty acid supplementation and reduction of traumatic axonal injury in a rodent head injury model.
In cases of severe injury, traumatic axonal injury may be present resulting in disconnection and significant disruption of axonal transport (Barkhoudarian, Hovda, & Giza, 2011).
Cutochrome c release and caspase activation in traumatic axonal injury.
He said a diffuse traumatic axonal injury was caused by the application of force, which shifted the brain inside the skull.
The paper is titled "Robust Detection of Traumatic Axonal Injury in Individual Mild Traumatic Brain Injury Patients: Intersubject Variation, Change Over Time and Bidirectional Changes in Anisotropy.
In experiments in rats that used a device that enabled simulation of the impact of trauma on human neurons, researchers have identified key molecular mechanisms by which implanted human neural stem cells aid recovery from traumatic axonal injury.
17) Axonal injury from hypoxic-ischemic injury is designated as vascular axonnal injury, and injury from acceleration-deceleration forces is diffuse traumatic axonal injury (dTAI).
sup][29] In previous studies, FA value tends to be more sensitive than other DTI indexes for assessing the microstructural integrity and cognitive function after traumatic axonal injury.

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