The exchange of sulfur, or sulfur-containing moiety, between two different compounds.
References in periodicals archive ?
Hydrogen sulfide (H[sub]2S) is generated in mammalian tissues from homocysteine and cysteine catalyzed by cystathionine a-synthase and cystathionine c-lyase, the key enzymes of the transsulfuration pathway of methionine metabolism.
2004); in response, homocysteine is permanently removed from the methionine cycle through degradation into cysteine in the transsulfuration cycle, where it is converted to cysteine and then to glutathione, a universal antioxidant (Schmidt and LaSalle 2011).
Cystathionine was generated by transmethylation in the process of Met metabolism [23], and then cystathionine transsulfuration produced cysteine [24], and cysteine finally transformed into taurine [25], which plays important roles in antioxidant [24].
S-adenosylmethionine (SAM): Common co-substrate involved in methyl group transfers, transsulfuration, and aminopropylation.
Its metabolism is at the intersection of two metabolic pathways: Remethylation and transsulfuration.
Homocysteine is metabolized in the body by either the transsulfuration or remethylation pathways.
The second step of this pathway involves the transsulfuration pathway, which converts homocysteine to cysteine and other products.
Miller, "The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine," The American Journal of Clinical Nutrition, vol.
Park, "Involvement of hydrogen sulfide and homocysteine transsulfuration pathway in the progression of kidney fibrosis after ureteral obstruction," Biochimica et Biophysica Acta-Molecular Basis of Disease, vol.
25) Homocysteine is converted to cystathionine to form cysteine via transsulfuration pathway, which is facilitated by two pyridoxal phosphate dependent enzymes, cystathionine synthase and cystathionase.
2]S biogenesis via alternative transsulfuration reactions.
Third, the transsulfuration pathway from homocysteine to cystathionine which is catalyzed by cystathionine beta synthase (CBS) is tightly related to the methylation pathway.