TFRC

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TFRC

A gene on chromosome 3q29 that encodes transferrin receptor, a protein required for development of erythrocytes and the nervous system.
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Erhardt JG, Estes JE, Pfeiffer CM, Biesalski HK and NE Craft Combined measurement of ferritin, soluble transferrin receptor, retinol binding protein, and C-reactive protein by an inexpensive, sensitive, and simple sandwich enzyme-linked immunosorbent assay technique.
Serum transferrin receptor (sTfR) is another marker which is a truncated form of the transferrin receptor present on erythroblasts in bone marrow and many other cells in the body.
Schmidt PJ, Toran PT, Giannetti AM, Bjorkman PJ, Andrews NC (2008) The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression.
The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer.
Role of transferrin receptor and the ABC transporters ABCB6 and ABCB7 for resistance and differentiation of tumor cells towards artesunate.
Gupta S, Uppal B, Pawar B, Is soluble transferrin receptor a good marker of iron deficiency anemia in chronic kidney disease patients?
An EIA for quantifying the level of transferrin receptor in human serum or plasma.
Function is modulated by other proteins under the control of genes for haemochromatosis (HFE) heamojuvelin and transferrin receptor 2.
For patients with intermediate serum ferritin levels (45-99 ng/dL), the soluble transferrin receptor (sTfR) level and the sTfR-ferritin index (ratio of sTfR to log ferritin) are highly sensitive and specific.
Now, they have found that an additional pair of genes that control iron import, called transferrin receptor and HFE, is also important.
Hemochromatosis has been associated more recently with mutations at the hemojuvelin (HJV), hepcidin (HAMP) and transferrin receptor 2 (TFR2) genes.