transdifferentiation

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transdifferentiation

(trănz″dĭf″ĕ-rĕn″shē-ā′shŭn)
The conversion of stem cells derived from one tissue into cells normally found in another tissue.

transdifferentiation

see alveolar2. Metaplasia.
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Human bone marrow stem cells (hBMSC) transdifferentiated into male germ like cells and expressed specific germ cell markers NANOG,OCT4, STELLA and male germ-cell markers such as DAZL, and SCP3 (Drusenheimer et al.
These biological and functional changes have warranted the application of a new name for these transdifferentiated adipose cells, the "beige" adipocyte [34], which are related to prolonged exposure to cold weather and [beta]-adrenergic agonist and whose characterization has been done in the last decade [35].
TNF-[alpha] activates macrophages derived from transdifferentiated adipocytes, inducing lipolysis and increasing the expression of several genes, such as intracellular adhesion molecule-1 (ICAM-1), IL-6, and monocyte chemoattractant protein-1 (MCP-1) [105,106].
Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes.
In 2010, Srivastava transdifferentiated mouse heart fibroblasts into beating heart muscle cells.
1997a) showed that corneas transdifferentiated into lens after exposure to centrifuged, filtered, retina-conditioned culture medium, thus indicating that some diffusible factor was responsible for inducing lens regeneration.
Do you see that as a significant competitor to iPS cell technology, and do you think that the same issues that you've identified for iPS cells will pertain to transdifferentiated cells?
Greg Chotkowski, DMD, president of StemSave[TM], a leading company in the field of stem cell recovery and cryo-preservation, said, "Dental stem cells have been transdifferentiated in the laboratory to form bone, nervous tissue and beta islet cells that produce insulin.
Studies in mice have shown that cells that have transdifferentiated from another type of adult stem cell can and do function according to the new phenotype.
Loss of active MEK1-ERK1/2 restores epithelial phenotype and morphogenesis in transdifferentiated MDCK cells.
Transcription factors C/EBPa and PPARy (Figure 5) identified quantitatively by real time PCR when porcine satellite cells were transdifferentiated in the presence of ciglitizone and when expressed in G8 myoblasts, can suppress the muscle-specific transcription factors (Myf5, MyoD, myogenin and MRF4) (Hu et al.