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transcobalamin
(redirected from Transcobalamins)

   Also found in: Wikipedia 0.01 sec.
transcobalamin /trans·co·bal·a·min/ (trans″ko-bal´ah-min) any of three plasma proteins (transcobalamins I, II, and III) that bind and transport cobalamin (vitamin B12). Abbreviated TC.
trans·co·bal·a·min (trnsk-bl-mn)
n.
Any of a family of cobalamin-binding proteins, deficiencies of which have been associated with low serum cobalamin levels.

transcobalamin [trans″ko-bal´ah-min]
either of two plasma proteins, transcobalamin I and transcobalamin II, that bind and transport cobalamins, including vitamin B12 (see vitamin). Deficiency of transcobalamin II results in failure of immunoglobulin production, megaloblastic anemia, granulocytopenia, thrombocytopenia, and intestinal villous atrophy, and is correctable by vitamin B12 therapy.

transcobalamin
a group of proteins (of intestinal cells) that bind to cyanocobalamin (vitamin B12) and transport it to other tissues.


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The vitamin is well retained in plasma and cells due to binding to specific proteins called transcobalamins or to B12-dependent enzymes, and unlike with most B vitamins, there are minimal losses of B12 in urine.
 
 
 
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