toxicokinetics


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toxicokinetics

[tok′sikō′kinet′iks]
the passage through the body of a toxic agent or its metabolites, usually in an action similar to that of pharmacokinetics.

toxicokinetics

The study of the absorption, distribution, metabolism, and elimination of hazardous substances by an organism.
References in periodicals archive ?
What we see is that each chemical can significantly alter the other chemical's toxicokinetics [i.
Toxicokinetics deals with the absorption, distribution, metabolism and excretion (ADME) of compounds in an organism.
In vivo acetylcholinesterase inhibition, metabolism, and toxicokinetics of aldicarb in channel catfish: role of biotransformation in acute toxicity.
Toxicological study design considerations include species selection (default to rat and dog) and pharmacological considerations, compound metabolic/PK profile; testing of the quality of the drug candidate; formulation; dose-exposure linearity information; study duration; clinical endpoints (clinical observations, body weight, food consumption); pathology endpoints (clinical pathology and gross and histopathology) and toxicokinetics.
This information, together with detailed toxicokinetics data, and in vitro-in vivo extrapolation algorithms forms the basis for improved hazard and risk assessment.
Early chapters examine molecular and cellular toxicology, covering topics on measuring toxicity and assessing risk; toxicokinetics, which is the phase of poisoning in which the poison undergoes movement within the body; biotransformation; cellular sites of action; genomics; and carcinogenesis.
A safety assessment of coumarin taking into account species-specificity of toxicokinetics.
The modeling topic of ENTOX mainly comprise (a) identification of the pathogen-pollutants and toxic stressor-effect relationship; (b) fate, behavior and transport of organic/non-organic toxic compounds degradation in exposure medium [2-4]; (c) absorption, distribution, metabolism and excretion of environmental contaminants within exposure sentinel species, human and animal [5-7]; (d) toxicokinetics (TK) and toxicodynamics (TD) mechanism at target sites [8]; and (e) risk assessment of toxic pollutant propagation from organisms to populations and variations in ecosystem sensitivities under various scenarios [5,9].
zillii exposed to glyphosate and its formulations are necessary to understand the mechanisms and toxicokinetics of the herbicide.
It discusses lead in the human environment, including its early history, production, uses, trends, emissions and emission trends, fate and transport processes, and concentrations in air, paint, food, water, soils, and dusts; nonoccupational lead exposure in human populations, including lead intakes, toxicokinetics and biomarkers of exposure, predictive modeling approaches for assessing exposure, and the environmental epidemiology of exposure; toxicity in various body systems; human health risk assessment; and regulatory policies in the US and approaches for lead in paint, air, water, and food.
While health effect information is the primary focus of the profiles, other relevant information is presented in these chapters such as toxicokinetics, environmental fate, mechanisms of toxicity, children's exposure and susceptibility, biomarkers of exposure and effect, and methods for reducing toxic effects.