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Tn syndrome

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Tn syndrome
Hematology A chronic myelodysplasia associated with polyagglutination of RBCs Clinical Severe thrombocytopenia, hemolytic anemia, leukopenia; RBCs and platelets lack T-transferase–UDPGal:GalNAc-β-3-D-galactosyltransferase, resulting in inability to express GPIb glycoprotein and cryptantigen Tn, which reacts with naturally-occurring antibodies, causing global hemolysis and clotting


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