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Tissue plasminogen activator

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tissue plasminogen activator

n. Abbr. TPA

1. An enzyme that catalyzes the conversion of plasminogen to plasmin, used to dissolve blood clots rapidly and selectively, especially in the treatment of heart attacks.

2. A preparation of this enzyme that is produced by genetic engineering and used to dissolve clots blocking coronary arteries in heart attack and cranial arteries in certain cases of stroke.

Tissue plasminogen activator (tPA)

A substance that is sometimes given to patients within three hours of a stroke to dissolve blood clots within the brain.

Mentioned in: Stroke

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