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tirofiban

   Also found in: Wikipedia 0.02 sec.
tirofiban /ti·ro·fi·ban/ (ti″ro-fi´ban) a platelet inhibitor, used as the hydrochloride salt in prophylaxis of thrombosis in unstable angina or in myocardial infarction that is not characterized by abnormal Q waves.
tirofiban,
an antiplatelet agent.
indication It is used to treat acute coronary syndrome.
contraindications The following factors prohibit its use: known hypersensitivity to this drug, active internal bleeding, stroke, major surgery, severe trauma, intracranial neoplasm, aneurysm, and hemorrhage.
adverse effects Bleeding is a life-threatening effect of tirofiban. Other adverse reactions include bradycardia, dizziness, dissection, coronary artery edema, pain in the legs and/or pelvis, and sweating. Rash is a common side effect.
tirofiban [ti″ro-fi´ban]
a platelet inhibitor, used as the hydrochloride salt in prophylaxis of thrombosis in unstable angina or in myocardial infarction that is not characterized by abnormal Q waves; administered intravenously.
tirofiban
Aggrastat®, MK-383 Cardiology A potent short-acting, nonpeptide inhibitor of platelet glycoprotein IIb/IIIa or integrin αIIbβ3 receptor which, when administered with heparin, ↓ ischemic events in Pts with acute coronary syndrome. See PRISM, PRISM-PLUS.
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A standard treatment for patients with troponin-positive acute coronary syndrome is tirofiban which is a "short-acting non-peptide inhibitor of the GPIIb/IIIA receptor.
What's new in hemostasis? by Isabel, Jeanne M. / Medical Laboratory Observer
Among patients with high risk NSTE ACS (ie, with ST depression on ECG and/or elevated markers of cardiac necrosis), precath lab therapy with either eptifibatide or tirofiban plus unfractionated heparin was associated with a 10 to 20% decrease in death/MI.
Non-ST segment elevation acute coronary syndromes: a comprehensive ... by Januzzi, James L., Jr. / Southern Medical Journal
In contrast, data on all patients in the lamifiban trial show just a modest, statistically insignificant improvement, similar to that seen in tests of eptifibatide and tirofiban, two other intravenous-use GP IIb/IIIa receptor inhibitors already on the market.
Tailoring Use of Platelet Inhibitors by USA Today (Magazine)
 
 
 
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