tinidazole


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tinidazole

Fasigyn, Tindamax

Pharmacologic class: Antiprotozoal

Therapeutic class: Anti-infective

Pregnancy risk category C

FDA Box Warning

Prolonged use of metronidazole (a structurally related drug with similar biologic effects) has caused cancer in mice and rats. Reserve tinidazole for conditions listed under "Indications and dosages."

Action

Free nitro radical (generated from tinidazole reduction by Trichomonas cell extracts) may explain activity against Trichomonas species; activity against Giardia and Entamoeba species is unknown.

Availability

Tablets: 250 mg, 500 mg

Indications and dosages

Trichomoniasis caused by Trichomonas vaginalis

Adults: Single dose of 2 g P.O. with food, given to both sexual partners simultaneously

Bacterial vaginosis in nonpregnant females

Adults: 2 g P.O. once daily with food for 2 days, or 1 g P.O. once daily with food for 5 days

Giardiasis caused by Giardia duodenalis (Giardia lamblia)

Adults: Single dose of 2 g P.O. with food

Children older than age 3: Single dose of 50 mg/kg (up to 2 g) with food

Amebiasis caused by Entamoeba histolytica

Adults: 2 g P.O. daily with food for 3 days

Children older than age 3: 50 mg/kg (up to 2 g) P.O. daily with food for 3 days

Amebic liver abscess caused by E. histolytica

Adults: 2 g P.O. daily with food for 3 to 5 days

Children older than age 3: 50 mg/kg (up to 2 g) P.O. daily with food for 3 to 5 days

Dosage adjustment

• Hemodialysis patients

Contraindications

• Hypersensitivity to drug, its components, or other nitroimidazole derivatives
• First trimester of pregnancy

Precautions

Use cautiously in:
• CNS disease, hepatic dysfunction
• history of blood dyscrasias
• elderly patients
• pregnant or breastfeeding patients
• children (except to treat giardiasis and amebiasis in children older than age 3).

Administration

• Give with food to minimize GI discomfort.

Adverse reactions

CNS: weakness, fatigue, malaise, dizziness, vertigo, ataxia, insomnia, drowsiness, giddiness, headache, transient peripheral neuropathy, seizures

CV: palpitations

GI: nausea, vomiting, diarrhea, constipation, dyspepsia, gastric discomfort, tongue discoloration, stomatitis, anorexia

Hematologic: transient neutropenia and leukopenia

Musculoskeletal: arthralgia, myalgia, arthritis

Other: altered taste, overgrowth of susceptible organisms, hypersensitivity reactions including angioedema

Interactions

Drug-drug. Cyclosporine, lithium, tacrolimus: possible increase in blood levels of these drugs

Cholestyramine: decreased oral bioavailability of tinidazole

CYP450 inducers (such as phenobarbital, rifampin): increased tinidazole elimination and decreased blood level

CYP450 inhibitors (such as cimetidine, ketoconazole): increased tinidazole blood level

Fluorouracil: decreased fluorouracil clearance

Fosphenytoin, phenytoin: prolonged half-life and reduced clearance of these drugs

Oxytetracycline: antagonism of therapeutic effects of tinidazole

Warfarin, other oral coumarin anticoagulants: increased effects of these drugs

Drug-diagnostic tests. Alanine aminotransferase, aspartate aminotransferase, hexokinase glucose, lactate dehydrogenase, triglycerides: interference with test results

Drug-behaviors. Alcohol use: disulfiram-like reaction during tinidazole therapy and for 3 days after

Patient monitoring

Closely monitor patient for neurologic abnormalities, such as seizures and peripheral neuropathy. If these occur, withdraw drug immediately.

tinidazole

an antiprotozoal.
indications This drug is used to treat amebiasis, giardiasis, and trichomoniasis.
contraindications First-trimester pregnancy and known hypersensitivity to nitroimidazole derivative or to this drug prohibit its use.
adverse effects Adverse effects of this drug include anorexia, increased aspartate aminotransferase and alanine aminotransferase, constipation, abdominal pain, neutropenia, pruritus, urticaria, and oral monilia. Life-threatening side effects include seizures, leukopenia, and angioedema. Common side effects include dizziness, headache, peripheral neuropathy, nausea, vomiting, and rash.

tinidazole

Parasitology An antiprotozoal used to treat amebiasis, giardiasis, trichomoniasis, and H pylori infections in Pts with low-grade gastric lymphoma

tinidazole

An antibacterial and antiprotozoal drug similar to METRONIDAZOLE but with a longer duration of action. It is used to treat AMOEBIASIS, TRICHOMONIASIS and GINGIVITIS. A brand name is Fastigyn.

tinidazole

an analog of metronidazole with a longer half-life but similar activity and uses.
References in periodicals archive ?
The 10-day sequential therapy included 1 mg/kg/day omeprazole plus 50 mg/kg/day amoxicillin for 5 days followed by 1 mg/kg/day omeprazole plus 15 mg/kg/day clarithromycin plus 20 mg/kg/day tinidazole for the next 5 days.
The measurement of tiny amount of tinidazole by using the modified electrode was carried out through linear scanning voltametry method, and a detection range of about 10 nanomolar was obtained for it.
pylori are achieved by triple therapy consisting of a combination of two antibiotics [amoxicillin (AMC), clarithromycin (CAM), tinidazole (TNZ) and metronidazole (MNZ)] and one proton pump inhibitor (PPI) [omeprazole (OPZ), lansoprazole (LPZ), pantoprazole (PPZ) or rabeprazole (RPZ)].
He was treated with a one-week course of triple therapy (omeprazole 20 mg twice daily, clarithromycin 500 mg twice daily, and tinidazole 500 mg twice daily).
Pfizer has marketed 500mg oral tablets of tinidazole in Europe (under the trade name Fasigyn) since receiving approval in 1994.
lamblia while traveling in India; although PCR indicated that the strains from all 4 patients were genetically identical, responses to treatment with tinidazole varied (11).
Chlorogenic acid, galuteolin and tinidazole (using as internal standard, IS) were purchased from National Institute for the Control of Pharmaceutical and Biological Products.
Specifically, a marked improvement or worsening of a serious medical problem or function is observed with a spirochete-killing treatment; for example, doxycycline, tetracycline, minocycline, any penicillin such as amoxicillin, azithromycin, clarithromycin, cefuroxime, metronidazole, R-5081, antibiotic herbs, or essential oils and tinidazole.
The remaining 25% increase in sales was attributable to the increase in unit sales price for certain highly demand products, such as Ferrous Fumarate Granule, Eucommia Ulmoides Oliv Granule, Tinidazole Vaginal Effervescent Tablet, Bushen Qiangshen Tablet, and Ranitidine Hydrochloride Capsule.
pylori but the best results are achieved by triple therapy consisting of a combination of two antibiotics [amoxicillin (AMC), clarithromycin (CAM), tinidazole (TNZ) and metronidazole (MNZ)] and one PPI (41).
Single-dose tinidazole 2 g will be recommended for initial treatment or treatment failure.
130,131) A shorter duration of therapy has been shown to be efficacious with metronidazole, and other nitroimidazoles such as tinidazole or ornidazole are effective; however, the latter agents are not available in the United States.