Tilade

Ti·lade (tld)

A trademark for the drug nedocromil sodium.

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nedocromil sodium

Tilade

Pharmacologic class: Mast cell stabilizer

Therapeutic class: Antiasthmatic

Pregnancy risk category B

Action

Blocks allergen-triggered release of histamine and slow-releasing substance of anaphylaxis from mast cells, decreasing overall allergic response and inflammatory reaction

Availability

Aerosol for inhalation: 1.75 mg/spray in 16.2-g canister

⊘Indications and dosages

➣ Maintenance therapy in mild to moderate bronchial asthma

Adults and children ages 6 and older: Two inhalations (1.75 mg/spray) two to four times daily

Contraindications

• Hypersensitivity to drug or its components

Precautions

Use cautiously in:
• acute asthma attack
• pregnant or breastfeeding patients
• children younger than age 6 (safety not established).

Administration

• Know that drug isn't indicated for bronchospasm reversal in acute asthma attack.
☞ Stop drug immediately if bronchospasm occurs.
• Be aware that therapeutic response may take up to 4 weeks.

Route	Onset	Peak	Duration
Inhalation	Unknown	30 min	3.5 hr

Adverse reactions

CNS: headache

CV: chest pain

EENT: conjunctivitis, rhinitis, sinusitis, pharyngitis

GI: nausea, diarrhea, abdominal pain

Respiratory: cough, upper respiratory tract infection, increased sputum, bronchitis, dyspnea, worsening of bronchial asthma, bronchospasm

Other: unpleasant taste, viral infection, hypersensitivity reactions including anaphylaxis

Interactions

None significant

Patient monitoring

• Monitor pulmonary function tests.
• Assess respiratory status frequently.
☞ Watch for increasing bronchospasm and anaphylaxis.

Patient teaching

• Advise patient to expectorate mucus from airway before using inhaler.
• Provide instructions on proper inhalation technique.
• Encourage patient to use spacer as needed to achieve therapeutic dosage.
• Tell patient to gargle and sip water after inhalation, to reduce mouth irritation.
• Inform patient that therapeutic response may take up to 4 weeks.
• Inform patient that drug should be used only for asthma prevention and not as rescue inhaler in emergencies.
• As appropriate, review all other significant and life-threatening adverse reactions.

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Tilade®

Nedocromil nebulizer Respiratory medicine An inhalable NSAID used as maintenance therapy in Pts with asthma See Asthma.