ticlopidine


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Related to ticlopidine: dipyridamole, ticlopidine hydrochloride

ticlopidine

 [ti-klo´pĭ-dēn]
a platelet inhibitor used as the hydrochloride salt in the prevention of stroke syndrome.

ticlopidine

/ti·clo·pi·dine/ (ti-klo´pĭ-dēn) a platelet inhibitor used as the hydrochloride salt in the prophylaxis of stroke syndrome.

ticlopidine

(tī-klō′pə-dēn′)
n.
A drug that blocks platelet aggregation, C14H14ClNS, used in its hydrochloride form to prevent stroke and to treat intermittent claudication.

ticlopidine

[tiklo′pidēn]
a platelet inhibitor used as the hydrochloride salt in the prevention of stroke syndrome.

ticlopidine

Therapeutics A platelet aggregation inhibitor that alters the platelet membrane, interfering with membrane-fibrinogen interaction by blocking platelet gpIIb/IIIa receptor Indications ↓ Stroke in high risk Pts, minimize stroke progression, cerebral ischemia, progression of diabetic retinopathy Side effects BM suppression with severe reversible neutropenia, diarrhea, rash, gastritis or gastric ulcers–nausea, dyspepsia, hemorrhage, thrombocytopenia, ↑ cholesterol. See TIA.

ticlopidine

A thienopyridine drug that interacts with platelet glycoprotein in such a way as to inhibit platelet function. It has been found useful in preventing vein grafts from becoming occluded by thrombosis.

ticlopidine (tīklō´pədēn),

n brand name: Ticlid;
drug class: platelet aggregation inhibitor;
action: inhibits first and second phases of adenosine diphosphate (ADP)-induced effects in platelet aggregation;
use: effective in reducing the risk of stroke in high-risk patients.

ticlopidine

an antiplatelet drug used in thrombotic diseases such as heartworm disease in dogs.
References in periodicals archive ?
Impaired platelet responses to clopidogrel and ticlopidine in a patient with recurrent coronary stent stenosis.
Vice president of sales Jack Bleau says the ability to be first to market with ticlopidine hydrochloride has given Apotex a high level of credibility.
Drug-Induced Glomerular/Vascular Injury Glomerulonephritis Anti-tumor necrosis factor [alpha] agents Infliximab Adalimumab Etanercept Thrombotic microangiopathy Anti-vascular endothelial growth factor agents Bevacizumab Immunosuppressive agents * OKT3 Sirolimus Clopidogrel Ticlopidine Antiviral agents Acyclovir Valacyclovir Focal segmental glomerulosclerosis Classic variant Sirolimus Collapsing variant Bisphosphonates Pamidronate Alendronate * Especially when used in a calcineurin inhibitor-based regimen.
The Ticlopidine Aspirin Stroke Study (TASS) examined the effects of ticlopidine 500 mg versus aspirin 1300 mg on the risk of stroke or death in 3069 patients with recent ischemic events.
Both have a good side effect profile, while ticlopidine, shown to reduce the risk of stroke 21% over aspirin alone, has some dangerous side effects in a small proportion of patients, he added.
The Food and Drug Administration last month approved the suppliers's abbreviated new drug application (ANDA) of ticlopidine, rating it therapeutically equivalent to the product launched by Roche in October 1991.
9,22,26] Medical management consists of risk factor control, principally control of hypertension and stopping smoking, and antiplatelet drugs such as aspirin or ticlopidine.
Aspirin, ticlopidine, and the combination of dipyridamole plus aspirin are all effective antiplatelet agents for secondary stroke prevention.
The FDA is urging physicians to consider use of other antiplatelet agents in poor metabolizers, such as ticlopidine (Ticlid) or prasugrel (Effient), or potentially increasing the clopidogrel dose.
demonstrate antiplatelet therapy with clopidogrel or ticlopidine to be equally effective in reducing intimal hyperplasia in an experimental arterial injury animal model (1).
Ticlopidine is beneficial for various vascular conditions, but frequent side effects--some serious--limit its usefulness.