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Thyroxin

   Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia, Hutchinson 0.03 sec.
Thyroxin
The hormone secreted by the thyroid gland.
Mentioned in: Goiter

thyroxine, thyroxin
a hormone of the thyroid gland that contains iodine and is a derivative of the amino acid tyrosine. The chemical name for thyroxine is tetraiodothyronine (symbol, T4); it is formed and stored in the thyroid follicles as thyroglobulin, the storage form. Thyroxine is released from the gland by the action of a proteolytic enzyme. T4 is deiodinated in peripheral tissues to form tri-iodothyronine (T3), which has a greater biological activity.
Thyroxine acts as a catalyst in the body and influences a great variety of effects, including metabolic rate (oxygen consumption); growth and development; metabolism of carbohydrates, fats, proteins, electrolytes and water; vitamin requirements; reproduction; and resistance to infection.
Thyroxine can be extracted from animals or made synthetically; it is used in the treatment of hypothyroidism and some types of goiter.

free thyroxine
the metabolically active fraction of thyroxine; abbreviated FT4, Tf. T4 = Tf + TBG. The amount is very small and difficult to estimate so that the amount present in serum is not used as a more accurate indicator of thyroxine status than T4.
thyroxine-binding globulin (TBG)
most (99.95%) of the thyroxine in plasma is bound to globulin and a small amount bound to prealbumin.
thyroxine-binding prealbumin
bound to a small fraction of circulating T4. This is the only known function of prealbumins.
L-thyroxine


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