NKX2-1

(redirected from Thyroid Transcription Factor 1)
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NKX2-1

A gene on chromosome 14q13 that encodes a transcription factor which binds and activates the promoter of thyroid-specific genes—e.g., for thyroglobulin, thyroperoxidase and thyrotropin receptor. NKX2-1 is crucial in the maintenance of the thyroid differentiation phenotype, and it may play a role in lung development and surfactant homeostasis.
References in periodicals archive ?
Evaluation of napsin A, cytokeratin 5/6, p63, and thyroid transcription factor 1 in adenocarcinoma versus squamous cell carcinoma of the lung.
Thyroid transcription factor 1 and cytokeratins 1, 5, 10, 14 (34betaE12) expression in basaloid and large-cell neuroendocrine carcinomas of the lung.
for thyroid transcription factor 1 (TTF-1) by RNAscope assay (A and C) that were negative by immunohistochemistry assays (B and D) (original magnification X400 [A and C]; TTF-1, original magnification X400 [B and D]).
Thyroid transcription factor 1 expression in ovarian carcinomas is an independent prognostic factor.
Thyroid transcription factor 1 can be helpful in some of these cases because thymic TC and AC are negative for TTF1.
Large cell carcinoma with undifferentiated and basaloid components and with strong thyroid transcription factor 1 (TTF-1) expression.
Thyroid transcription factor 1 is a 38-kDa homeodomain protein that shows nuclear-specific staining.
Utility of tissue-specific transcription factors thyroid transcription factor 1 and Cdx2 in determining the primary site of metastatic adenocarcinomas to the brain.
Previously performed immunohistochemical stains for thyroid transcription factor 1 (TTF-1) (n = 5) and cytokeratins (AE1/AE3 + CAM5.
The antibodies used included prostate-specific antigen (PSA); [alplha]-methylacyl-CoA racemase, high-molecular-weight cytokeratin and p63 protein cocktail (PIN4); cytokeratin 7 (CK7); cytokeratin 20 (CK20); epithelial membrane antigen (EMA); mucin type 1 sialoglycoprotein (MUC1); cluster of differentiation 31/platelet-endothelial cell adhesion molecule 1 (CD31); thyroid transcription factor 1 (TTF1); caudal-related homeobox 2 (CDX2); and Wilms tumor protein 1 (WT1).
The immunohistochemistry profile of this tumor is distinctive, as the combination of cytokeratin and thyroid transcription factor 1 is generally diagnostic (Figure 2C, D).
Sensitivity (SEN), Specificity (SPEC), Positive Predictive Value (PPV), and Negative Predictive Value (NPV) for Immunohistochemistry in Adenocarcinoma TTF-1 (Dako), (a) Napsin A, TTF-1 (Leica), (b) Adenocarcinoma % % % SEN 20 (c) 83 60 SPEC 100 98 98 PPV 100 99 97 NPV 37 (c) 74 69 (a) Thyroid transcription factor 1 (TTF-1) from Dako (Carpinteria, California).