thromboxanes


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Related to thromboxanes: Eicosanoids, Leukotrienes

throm·box·anes

(throm-boks'ānz),
A group of compounds, included in the eicosanoids, formally based on thromboxane, but with the terminal COOH group present; biochemically related to the prostaglandins and formed from them through a series of steps involving the formation of an endoperoxide (an O-O bridge between carbons 9 and 11 in the prostaglandins) by a cyclooxygenase, followed by a rearrangement (catalyzed by thromboxane synthase) that inserts one of the two oxygen atoms between carbons 11 and 12, leaving the other still bridging carbons 9 and 11. Thromboxanes are so named from their influence on platelet aggregation and the formation of the oxygen-containing six-membered ring (pyran or oxane). Like the prostaglandins, individual thromboxanes (abbreviated TX) are designated by letters (A, B, C, etc.) and subscripts indicating structural features.

throm·box·anes

(throm-bok'sānz)
A group of compounds, included in the eicosanoids, formally based on thromboxane, but with the terminal COOH group present; biochemically related to the prostaglandins and formed from them. Thromboxanes are so named from their influence on platelet aggregation and the formation of the oxygen-containing six-membered ring (pyran or oxane). Like the prostaglandins, individual thromboxanes (abbreviated TX) are designated by letters (A, B, C, and onward) and subscripts indicating structural features.

thromboxanes

Substances similar to the prostaglandins that promote blood clotting. Aspirin in small doses reduces the production of thromboxane by PLATELETS.
References in periodicals archive ?
It has been postulated that, by disturbing the balance between thromboxane and prostacyclin, COX-2s may be prothrombotic.
Bennett says they apparently reduce thromboxane synthesis and the clumping of blood-clotting cells called platelets.
Conversely, a diet high in [omega]-6 EFAs, such as the Standard American Diet, results in the production of inflammatory prostaglandins, thromboxanes, leukotrienes, and other metabolites of arachidonic acid (AA; 20:5n-3), which, in turn, contributes to the formation of thrombi and atheromas, allergic and inflammatory consequences, and cellular proliferation.
Platelet activation is measurable by quantifying thromboxanes, platelet factor 4, and thrombomodulin (TM).
2]-antiplasmin, and t-PA/PAI complexes Platelets Thromboxanes, platelet factor 4, TM, and soluble P-selectin Vascular injury/distress PAI-1, S-TM, adhesion molecules, and P,E,L-selectins Table 2.
On the other hand, thromboxane BZ is generated during the activation of platelets by the enzymatic action of cyclooxygenase on arachidonic acid.
12,13) The specific inhibition of COX-2 alters the balance between platelet-derived thromboxane [A.
I also briefly summarize the biochemical and pathophysiological properties of the two other PGE synthases (PGESs) and thromboxane synthase (TXS), which is closely related to PGIS.
1985) Isolation and characterization of thromboxane synthase from human platelets as a cytochrome P-450 enzyme.
The F2-isoprostane, 8-epiprostaglandin-F2-[alpha], a potent agonist of the vascular thromboxane endoperoxide receptor, is a platelet thromboxane endoperoxide receptor antagonist.
Cardiovascular responses to the isoprostanes iPF(2 [alpha])-III and iPE(2)-III are mediated via the thromboxane A(2) receptor in vivo.