thrombospondin

(redirected from Thrombospondin 1)

thrombospondin

/throm·bo·spon·din/ (throm″bo-spon´din) a glycoprotein that interacts with a wide variety of molecules, including heparin, fibrin, fibrinogen, platelet cell membrane receptors, collagen, and fibronectin, and plays a role in platelet aggregation, tumor metastasis, adhesion of Plasmodium falciparum, vascular smooth muscle growth, and tissue repair in skeletal muscle following crush injury.

thrombospondin

(throm″bō-spon′dĭn),

TSP

A glycoprotein that prevents cell-to-cell adhesion and angiogenesis. Thrombospondin is secreted by some parasites and may enhance their ability to cause disease. It is also found in malignant tumors, where it may block tumor growth and metastasis.

thrombospondin

an osteoblast product which binds to connective tissues and serum proteins and binds calcium to hydroxyapatite and to osteonectin.
References in periodicals archive ?
Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling.
Plasma thrombospondin 1 as a predictor of postoperative liver dysfunction.
sup][25] showed that CD133(+) bone marrow-derived stem cells induced proliferation of endometrial surrounding cells through paracrine molecules such as thrombospondin 1 and insulin-like growth factor 1.
1] [19], GP1b[alpha] [20], vitronectin [21], and thrombospondin 1 [22].
Additional promising biomarkers for the early diagnosis and management of CI-AKI may be the cysteine rich protein 61 (CYR61), induced in the kidney within one hour after ischemic/toxic injury and detectable in the urine 3-6 hours later [77], KrUppel-like factor 6 (Zf9), a KrUppel-like transcription factor involved in the regulation of a number of downstream targets [78], thrombospondin 1 (TSP-1), a p53-dependent proapoptotic and antiangiogenic molecule [79], and IL-18, a proinflammatory cytokine that is known to be induced and cleaved in the proximal tubule and subsequently easily detected in the urine following ischemic AKI in animal models [80].
Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy.
03 in 17 chromosome 1 [Q09760] AA080628 phosphoribosylformylglycin amidine 7 synthase [P35421] AA080629 ORF 1130 [U20247] 6 AA080630 human thrombospondin 1 precursor 7 [P07996] AA080632 URP5 [1204259B] 16 AA080631 ERCC5 [D16305] 6 AA080635 murine erythroleukemia cardiac calcium 5 channel [U17869] AA080637 ORF gene product [X95373] 7 AA080638 latent transforming growth factor 8 beta-binding protein 3 precursor [A57293] AA080641 aminopeptidase [U35646] 28 AA080643 TO8A11.
11-16) Interestingly, an abnormal stromal-epithelial interaction, with increased expression of messenger RNA for vascular endothelial growth factor, fibronectin, thrombospondin 1, and other factors involved in the formation of vascular stroma, and analogous to that noted in wound healing responses, has been reported in radial scars.
Example: Thrombospondin 1 (TSP1); kallikreins 2, 3, 5, and 11; and early prostate cancer antigen-2 (EPCA-2) were no go for further validation studies after they failed in a blinded test on an EDRN prostate cancer reference set.
In the NG-treated platelets, there were increase in the levels of growth factor receptor-bound protein 2 (Grb2), thrombospondin 1, tubulin alpha 6 and decrease in the levels of thioredoxin, Cu-Zn superoxide dismutase, DJ-1 protein, peroxiredoxin 3, thioredoxin-like protein 2, ribonuclease inhibitor, potassium channel subfamily V member 2, myosin regulatory light chain 9 and laminin receptor 1.
The markers approved for prevalidation were human kallikrein 2 (hk2), hk4, hk11, thrombospondin 1, percent [-2]proPSA, and EPCA2 (early prostate-specific antigen 2).
Angiogenic macrophages produce the angiogenesis inhibitor thrombospondin 1.