Trx-1 reduces hydrogen peroxide via peroxiredoxin (Prx) and oxidized Trx-1 is reduced by thioredoxin reductase
Carrageenan exposure and ROS production inhibited thioredoxin reductase
activity and increased oxidation of nucleoredoxin.
The important metabolic functions of Se are supposed to be due to the protection of membrane lipids and macromolecules from oxidative damage by combating against reactive oxygen species; and the activation of antioxidant proteins including glutathione peroxidase, thioredoxin reductase
, leading to decreased levels of hydrogen peroxide.
The mammalian thioredoxin reductase
is a selenoprotein that cannot be produced in bacteria.
They found that for the first time, patients who have SSV within a certain nerval distribution involving skin and eyelashes show the same oxidative stress as observed in the much more frequent general NSV, which is associated with decreased antioxidant capacities including catalase, thioredoxin reductase
, and the repair mechanisms methionine sulfoxide reductases.
mexicana has no genes for glutathione reductase (GR), thioredoxin reductase
(TrxR), catalase and selenocysteine-containing glutathione peroxidase which are responsible for intracellular thiol redox homeostasis in mammals (4).
We also tested (in vitro, both cellular and chemical) whether Ag ions could inhibit the activity of a key selenoenzyme, thioredoxin reductase
(TrxR) enzyme activity was determined by measuring the NADPH-dependant reduction of DTNB to TNB.
In the cytosol, both the thioredoxins and the glutaredoxins are maintained in a reduced state by the action of thioredoxin reductase
(TrxB) and glutathione, respectively (21).
The enzymes glutathione peroxidase (b) and thioredoxin reductase
(d) are selenium-dependent enzymes and selenoprotein P (c) is the transport protein for selenium.
In June, SemBioSys was issued United States Patent 6,750,046 entitled, "Preparation of Thioredoxin and Thioredoxin Reductase
Proteins on Oilbodies," and United States Patent 6,753,167 entitled, "Preparation of Heterologous Proteins on Oilbodies.
Selenium confers its antioxidant protection mainly through two enzymes that contain it--glutathione peroxidase and thioredoxin reductase