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Therapeutic Window

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Therapeutic Window
A well-defined range of a drug’s serum concentration at which a desired effect occurs, below which there is little effect, and above which toxicity occurs; the window differs among patients and may be determined empirically
therapeutic window
The well-defined range of a drug's serum concentration at which a desired effect occurs, below which there is little effect, above which toxicity occurs; the TW differs among Pts and may be determined empirically. Cf Therapeutic drug monitoring. Cf Window.
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This is important because previous studies focused on blocking the NMDA receptors in order to prevent cell death, but this approach didn't work because it affected normal cell function and had a relatively short therapeutic window.
New insights into post stroke cell death mechanism could offer ... by Asian News International
However, the use of thrombolytics (tPA) is limited due to the therapeutic window of < 3-6 hours post onset of stroke symptoms such that only a small fraction of stroke patients receive this therapy.
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On account of significant enterohepatic recirculation, and the fact that MPA excretion does not follow first-order kinetics, trough plasma MPA levels are inadequate to establish a therapeutic window of treatment efficacy and toxicity.
Mycophenolic acid metabolite levels in pediatric liver ... by Attard, Thomas M.; Dhawan, Anil; Tredger, J. Michael; Conner, Kim; Kling, Karen; Colombani, Paul; Th / Journal of Applied Research
 
 
 
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