Thalassemias


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Thalassemias

The name for a group of inherited disorders resulting from an imbalance in the production of one of the four chains of amino acids that make up hemoglobin. Thalassemias are categorized according to the amino acid chain affected. The two main types are alpha-thalassemia and betathalassemia. The disorders are further characterized by the presence of one defective gene (thalassemia minor) or two defective genes (thalassemia major). Symptoms vary, but include anemia, jaundice, skin ulcers, gallstones, and an enlarged spleen.
References in periodicals archive ?
5) Therefore, it is important to be aware of variables that complicate the laboratory diagnosis of thalassemias, and recognize when confirmatory genetic testing is indicated.
Talking to BSS on Thursday, eminent physician Dr Apurbo Pandit quoting Bangladesh Thalassemia Samity said at least 10 percent of the country's total population carry this disease, posing a serious threat to the public health with its current trend of rise.
The national thalassemia screening program for prevention of [beta]-thal major in Iran was initiated based on pre-marital screening since 1997 because of the high prevalence of [beta]-thalassemia.
Pattern of Thalassemias and other hemoglobinopathies: A study in district Dera Ismail Khan, Pakistan.
Therefore, in preventive and control programs, rapid, accurate, and inexpensive screening protocols to identify carriers of thalassemias and its variants, especially in population and families at risk for Hb disorders, are essential.
Thalassemia and other haemoglobinopathies are a group of hereditary disorders of haemoglobin (Hb) where there is quantitative and qualitative abnormal production or structure of Hb molecule, (1-2) a major public health problem in many parts of India.
Conclusion: Low serum calcium is very prevalent in transfusion-dependent beta thalassemia major patients in our set up possibly due to poor chelation as was confirmed by our study where 49% of patients had hypocalcemia.
Background Thalassemia is used to describe disorders with a significant decrease in the rate of synthesis of a globin chain.
PESHAWAR -- Thalassemia Control Program observe World Thalassamia Day on Thursday here at Peshawar Press ClubTalking a news press conference Hamza Foundation Chairman Ijaz Khan said that still Thalassemia Bill 210 was not implemented in the province and demanded the government to implement the bill.
The thalassemias are classified by a decrease or absent production of a specific globulin chain.
I congratulate the authors for exploring at the molecular level at least one of the thalassemia minima that fits well with the present clinical thalassemia nomenclature.
The prevalence of sickle cell anemia, beta-thalassemia major, beta thalassemia, alpha thalassemia, alpha thalassemia trait was found 0.