T helper cell

(redirected from Th1)
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T helper cell

see helper lymphocyte.
References in periodicals archive ?
Sprietsma (12) hypothesized that in zinc deficiency, interleukin-1 (IL-1) is incapable of stimulating a strong Th1 response.
Because apoptosis of mature T cells is a powerful mechanism for deleting T cells, it raises the interesting possibility that unequal apoptosis of Th1 and Th2 effector cells may lead to preferential deletion of one subset over another.
Regarding Th1 cytokines, IFNg knockout mice as well as TNF-a knockout mice surprisingly showed more severe EAE than wild-type mice.
Therefore, the aim of this study was to evaluate the serum concentrations of IL-13 (a Th2 type cytokine), IL-17 (a Th17 type cytokine) and IL-18 (an inducer of Th1 cells) in patients with IHD and also to clarify their association with traditional risk factors of disease.
Th1 inflammation and phosphorylation of axonal cytoskeleton in multiple sclerosis lesions.
balance TH1/TH2 durante la infeccion: 1) regula directamente la secrecion de IFN-[gamma] por las celulas TH1.
These results suggest that tuberculosis activates Th1 immune response due to increase of PBMC-IG.
They suggest that these high IL-10 levels could lead to down-regulation of the TH1 cells which would explain the low levels of IL-12 and IFN[gamma] in these patients.
1) The Th1 cells activated at the tuberculoid pole produce a strong CMI while Th2 cells activated at lepromatous pole inhibit Th1 cells resulting in defective CMI specific for M.
Th1 cells are primarily responsible for cell-mediated immunity, which means that they protect against intracellular pathogens such as fungi, yeasts, viruses, and mycobacteria.
Allergy is developed when the balance between Th1 and Th2 is disrupted.
IFN-[gamma], which is produced primarily by T-helper (Th) cells of the Th1 and Th0 subtypes, CD8+ T cells, and natural killer cells, is the main immunoregulator.