tetrahydrofolate


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tetrahydrofolate

H4 folate; a coenzyme derived from the reduction of folic acid through dihydrofolate; an important cofactor in the synthesis of purines.
References in periodicals archive ?
Second is the fact that some women may not have all the enzymes necessary to convert the synthetic form into tetrahydrofolate.
Common Mutation in the Methylenetetrahydrofolate Reductase Gene is Associated with an Accumulation of Formylated Tetrahydrofolates in Red Blood Cells.
In addition to CoA and SAM, many other cofactors like NAD, NADP, FAD, and ATP are all nucleotides or contain heterocyclic nitrogenous bases as seen in thiamin diphosphate (ThPP) and tetrahydrofolate (THF).
Folate status, homocysteine metabolism, and methylene tetrahydrofolate reductase genotype in rural South African blacks with a history of pregnancy complicated by neural tube defects.
Rima Rozen & Philippe Goyette, "Methods for detecting methylene tetrahydrofolate reductase allelic variants" U.
The metabolite 5, 10 methylene tetrahydrofolate is not formed, and this is specifically required for conversion of deoxyuridylate to thymidy-late, one of the four essential bases in DNA synthesis.
12] is a necessary cofactor for the conversion of 5-methyl-tetrahydrofolate to tetrahydrofolate, which can then reenter the pathway necessary for purine and thymine synthesis.
The preferred substrate for the enzyme that catalyzes this reaction is the tetrahydrofolate form of folic acid (22).
Assays involved the use of the 96-well microplate technique with standard 5-formyl tetrahydrofolate and assayed plasma.
One form of the present invention is a fused gene encoding for methylene tetrahydrofolate reductase (MTHFR) made up of an N-terminal domain from a yeast organism and a C-terminal domain from a plant species.