The company said the acquisition further expands its focus on treatments for severe and critical diseases in hepatic and renal conditions and diversifies its portfolio pipeline with differentiated, durable product, which aligns well with company's terlipressin
Since the main pathophysiology of HRS is splanchnic arterial vasodilatation and renal arterial vasoconstriction that causes increase in resistive index (RI) of renal arterial system and the terlipressin
(intravenously administered vasopressin 1 receptor agonist) causes selective vasoconstriction of splanchnic arterial vessels, which tends to reverse alterations in renal haemodynamic.
Gastroscopy revealed small low-risk esophageal varices (Figure 1a) and an active spurt from gastroesophageal varices type 2 (GOV2), which were successfully managed with intravenous terlipressin
and intravariceal N-butyl cyanoacrylate injection (Figure 1b).
, a provasopressin drug exhibits direct vasoconstrictor properties: consequences on heart perfusion and performance.
It has been shown by determining HVPG and observing waveform after administration of portal pressure lowering drugs like terlipressin
, that from 'monophasic' to 'biphasic' or 'biphasic' to 'triphasic', HVPG change (decrease) was always 3 mm of Hg or more.
sup] Moreover, in patients with norepinephrine-dependent septic shock, continuous low-dose vasopressin infusion resulted in hepatic perfusion damage;[sup] however, terlipressin
blunted the progressive decrease in the MAP without any detrimental effects on hepatosplanchnic perfusion, oxygen exchange, and metabolism.
Predictors of response to therapy with terlipressin
and albumin in patients with cirrhosis and type 1 hepatorenal syndrome.
It was treated conservatively with intravenous fluids, blood transfusion, and terlipressin
Inpatient treatment is usually required and may include norepinephrine with albumin, terlipressin
with midodrine, or octreotide and albumin.
Protective effect of the vasopressin agonist terlipressin
in a rat model of contrast-induced nephropathy"' American Journal of Nephrology, vol.
PharmaIN Corporation and LAT Pharma LLC announced the FDA has granted their request for orphan-drug designation for terlipressin
for the treatment of ascites due to all etiologies except for cancer.
So it is important to receive medical therapy with octreotide or terlipressin
with the aim of reducing portal pressure by inducing splanchnic vasodilation.