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teniposide

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teniposide /ten·i·po·side/ (ten-ĭ-po´sīd) a semisynthetic antineoplastic used in the treatment of neuroblastoma, non-Hodgkin's lymphoma, and acute lymphoblastic leukemia.
teniposide (VM-26) [ten´ĭ-po´sīd]
a semisynthetic derivative of podophyllotoxin, administered orally as an antineoplastic agent in treatment of neuroblastoma, non-Hodgkin's lymphoma, and acute lymphoblastic leukemia; administered intravenously.

teniposide
Vumon® Oncology An epipodophyllotoxin-type chemotherapeutic used in children with relapsed ALL and neuroblastomas, and adults with lymphoproliferative disorders Adverse effects Myelosuppression, N&V. See ALL.


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VM-26[R] or teniposide (Vumon[R]) for childhood leukemia, small cell lung cancer, and malignant brain tumors.
Eastman (29) showed that other inducers of apoptosis such as cisplatin induce apoptosis after 18-24 hr, whereas camptothecin or teniposide induce apoptosis in rat thymocytes even after 6 hr of exposure.
It is well known that DNA topoisomerase II is the target of a variety of anticancer drugs, such as etoposide, teniposide, and doxorubicin.
 
 
 
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