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telmisartan |
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telmisartan /tel·mi·sar·tan/ (tel?mi-sahr´tan) an angiotensin II antagonist used as an antihypertensive. telmisartan Micardis Pharmacologic class: Angiotensin II receptor antagonist Therapeutic class: Antihypertensive Pregnancy risk category C (first trimester), D (second and third trimesters) FDA Boxed Warning• When used during second or third trimester of pregnancy, drug may cause fetal harm or death. Discontinue as soon as pregnancy is detected. ActionInhibits vasoconstricting effects and blocks aldosterone-producing effects of angiotensin II at various receptor sites, including vascular smooth muscle and adrenal glands AvailabilityTablets: 20 mg, 40 mg, 80 mg ⊘Indications and dosages ➣ Hypertension Adults: 40 mg P.O. daily, titrated up or down within range of 20 to 80 mg daily based on response and tolerance Contraindications• Hypersensitivity to drug or its components PrecautionsUse cautiously in: Administration• Don't remove tablet from blister pack until just before giving.
Adverse reactionsCNS: dizziness, headache, fatigue CV: chest pain, peripheral edema, hypertension EENT: sinusitis, pharyngitis GI: nausea, vomiting, diarrhea, dyspepsia, abdominal pain GU: urinary tract infection Musculoskeletal: myalgia, back and leg pain Respiratory: cough, upper respiratory infection Other: pain, flu or flulike symptoms InteractionsDrug-drug. Antihypertensives, diuretics: increased risk of hypotension Digoxin: increased digoxin blood level Warfarin: decreased warfarin blood level Drug-diagnostic tests. Creatinine: slight elevation Drug-food. Any food: slightly reduced drug bioavailability Patient monitoring• Watch for signs and symptoms of hypotension. Patient teaching• Tell patient to take 1 hour before or 2 hours after meals. |
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