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Tapazole |
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methimazole Tapazole Pharmacologic class: Thiomidazole derivative Therapeutic class: Antithyroid drug Pregnancy risk category D ActionDirectly interferes with thyroid synthesis by preventing iodine from combining with thyroglobulin, leading to decreased thyroid hormone levels AvailabilityTablets: 5 mg, 10 mg ⊘Indications and dosages ➣ Mild hyperthyroidism Adults and adolescents: Initially, 15 mg P.O. daily in three equally divided doses at approximately 8-hour intervals. For maintenance, 5 to 15 mg/day in equally divided doses at approximately 8-hour intervals. Children: Initially, 0.4 mg/kg/day in three divided doses at 8-hour intervals. For maintenance, approximately 0.2 mg/kg/day in three divided doses at 8-hour intervals. ➣ Moderate hyperthyroidism Adults and adolescents: Initially, 30 to 40 mg P.O. daily in three equally divided doses at approximately 8-hour intervals. For maintenance, 5 to 15 mg/day in three equally divided doses at approximately 8-hour intervals. Children: 0.4 mg/kg/day P.O. as a single dose or in divided doses at 8-hour intervals. For maintenance, approximately 0.2 mg/kg/day as a single dose or in three divided doses at 8-hour intervals. ➣ Severe hyperthyroidism Adults and adolescents: Initially, 60 mg/day P.O. in three equally divided doses at approximately 8-hour intervals. For maintenance, 5 to 15 mg/day in three equally divided doses at approximately 8-hour intervals. Children: Initially, 0.4 mg/kg/day P.O. as a single dose or in three divided doses at 8-hour intervals. For maintenance, approximately 0.2 mg/kg/day as a single dose or in three divided doses at 8-hour intervals. Contraindications• Hypersensitivity to drug PrecautionsUse cautiously in: Administration• Give with meals as needed to reduce GI upset.
Adverse reactionsCNS: headache, vertigo, paresthesia, neuritis, depression, neuropathy, CNS stimulation GI: nausea, vomiting, constipation, epigastric distress, ileus, salivary gland enlargement, dry mouth, anorexia GU: nephritis Hematologic: thrombocytopenia, agranulocytosis, leukopenia, aplastic anemia Hepatic: jaundice, hepatic dysfunction, hepatitis Metabolic: hypothyroidism Musculoskeletal: joint pain, myalgia Skin: rash, urticaria, skin discoloration, pruritus, erythema nodosum, exfoliative dermatitis, abnormal hair loss Other: fever, lymphadenopathy, lupuslike syndrome InteractionsDrug-drug. Aminophylline, oxtriphylline, theophylline: decreased clearance of both drugs Amiodarone, iodine, potassium iodide: decreased response to methimazole Anticoagulants: altered requirements for both drugs Beta-adrenergic blockers: altered beta blocker clearance Digoxin: increased digoxin blood level Drug-diagnostic tests. Granulocytes, hemoglobin, platelets, white blood cells: decreased values Patient monitoring• Check for agranulocytosis in patients older than age 40 and in those receiving more than 40 mg/day. Patient teaching• Tell patient to take with meals if GI upset occurs. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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