tandem mass spectrometry


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tandem mass spectrometry (MS/MS)

a two-step technique used to analyze a sample for a predetermined set of substances, either by using a separate mass spectroscope for each step or by using the same spectroscope to perform the steps sequentially. In the first stage, a predetermined set of ions is selected for fragmentation; in the second, mass spectra are produced for the fragments. This technique is used in screening newborns for multiple metabolic disorders from a single blood sample.

multistage/mass spectrometry

An analytical procedure which recognises ions as reactive entities that can be interrogated. The prototype MS/MS instrument consists of two independently operated mass analysers linked by a reaction region in which the ion can be induced to react. Induction often occurs by collision (collision-induced dissociation) in which a selected higher-mass ion dissociates to a smaller fragment ion. In this simple conceptual instrument, three experiments are possible: precursor ion scan, product ion scan, and constant neutral loss scan. MS/MS recurring over multiple steps is known as MSn.

tandem mass spectrometry

Abbreviation: MS/MS
An analytical device that can rapidly assess the biochemical makeup of hundreds of specimens by measuring the mass-to-charge ratio of molecules. Synonym: tandem mass assay See: high-performance liquid chromatography; mass spectrometry

Patient care

It is used in clinical laboratories to screen newborn infants for metabolic disorders such as fatty acid oxidation deficiencies, organic acid disorders, and congenital adrenal hyperplasia.

See also: spectrometry
References in periodicals archive ?
Rapid and quantitative analysis of unconjugated C|27) bile acids In plasma and blood samples by tandem mass spectrometry.
Interactions of the theoretical variables of interest with the tandem mass spectrometry variable yielded similar substantive results.
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Quantitative analysis of amyloid beta peptides in cerebrospinal fluid of Alzheimer's disease patients by immunoaffinity purification and stable isotope dilution liquid chromatography/negative electrospray ionization tandem mass spectrometry.
MS/MS, or tandem mass spectrometry, available from the triple quadrupole option, is used to identify, confirm and quantify those contaminants.
Topics include using stable isotope tagging and mass spectrometry to characterize protein complexes and to detect changes in their composition, stable isotope labeling by amino acids in cell culture for quantitative proteomics, quantification of proteins and metabolites without isotopic labeling, an isotope coding strategy for proteomics involving both amine and carboxyl group labeling, tandem mass spectrometry in the detection of inborn errors of metabolism for newborn screening, computational analysis of quantitative proteomics data using stable isotope labeling, and quantitative proteomic analysis of phosphotyrosine-mediated cellular signaling networks.
Robust and sensitive mass spectrometer for quantitative determinations of known chemical substances at very low detection limits through the use of tandem mass spectrometry.
com/) announced today that it has entered into a collaborative agreement with Mayo Clinic to increase patient sample throughput and improve data quality using Cohesive's proprietary turbulent flow chromatography (TurboFlow(R) technology) systems for clinical assays using tandem mass spectrometry (MS/MS).
Part D, Practical Aspects of ES and MALDI, investigates analytical issues including quantification, charge-state distributions, noncovalent interactions in solution that are preserved as gas-phase ions, and various means of ion excitation in preparation for tandem mass spectrometry, and offers a guide to the interpretation of even-electron mass spectra
Contract notice: Supply and commissioning of a complete system of liquid chromatography coupled with tandem mass spectrometry (lc-ms / ms).