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Tamm-Horsfall protein

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Tamm-Horsfall protein (THP)
Etymology: Igor Tamm, American virologist, b. 1922; Frank L. Horsfall, American virologist, 1906-1971
a mucoprotein found in the matrix of renal tubular casts. THP is secreted in the loop of Henle.


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One of the discovered genes, the UMOD gene, produces Tamm-Horsfall protein, the most common protein in the urine of healthy individuals, which was recently found to be linked with chronic kidney disease risk.
Novel genetic risk factors for kidney disease identified by Asian News International
[2,3] Secretion of the Tamm-Horsfall protein increases with exercise, acute renal failure, kidney transplant rejection, and renal stones.
Laboratory evaluation of proteinuria by Baskin, Leland B.; Hsu, Rebecca M. / Medical Laboratory Observer
2 % CV Cross-Reactivity: Human and canine urine samples Tamm-Horsfall protein is the most abundant protein found in the urine of mammals.
MD Biosciences Releases Tamm-Horsfall (Uromodulin) ELISA by Business Wire
 
 
 
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