Tac antigen

Tac an·ti·gen

an antigenic determinant of the human interleukin 2 receptor that is identified by a murine monoclonal antibody, anti-Tac. Binding of this antigen with antibodies to TAC prevents the proliferation of T cells, which is normally stimulated by binding interleukin-2.

CD25

A 55-kD monomeric glycoprotein low-affinity receptor for IL-2–IL-2R alpha. With p75 beta chain—CD122 antigen, IL-2Rbeta—CD25 forms a high affinity IL-2R complex.

Normal expression
CD25 is expressed on activated T and B cells in the germinal centre, mantle zone, on activated macrophages and thymic medulla cells; it is absent from thymocytes and resting T and B cells.

Abnormal expression
Hairy cell leukaemia and Hodgkin lymphoma, and may be expressed on T and B cell NHLs, and HTLV I/II-associated T cell leukaemias.
References in periodicals archive ?
Global Markets Direct's, 'Interleukin-2 Receptor Subunit Alpha (IL-2 Receptor Subunit Alpha or TAC Antigen or p55 or CD25) - Pipeline Review, H1 2016', provides in depth analysis on Interleukin-2 Receptor Subunit Alpha (IL-2 Receptor Subunit Alpha or TAC Antigen or p55 or CD25) targeted pipeline therapeutics.
The report provides comprehensive information on the Interleukin-2 Receptor Subunit Alpha (IL-2 Receptor Subunit Alpha or TAC Antigen or p55 or CD25), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
The report provides a snapshot of the global therapeutic landscape for Interleukin-2 Receptor Subunit Alpha (IL-2 Receptor Subunit Alpha or TAC Antigen or p55 or CD25)
HuMAX-TAC is a human monoclonal antibody targeting the TAC antigen.