TYK2

TYK2

A gene on chromosome 19p13.2 that encodes a non-receptor protein tyrosine kinase, which phosphorylates IFN-alpha/beta receptor alpha chains and may be involved in intracellular signal transduction by initiating type-I IFN signalling.

Molecular pathology
TYK2 defects cause protein-tyrosine kinase 2 deficiency.
References in periodicals archive ?
As an example, the signals of both IL-10 and IL-22 go through IL-10R2 to activate JAK1 and TYK2, respectively, thus resulting in STAT3 activation.
E6 binds to TYK2 preventing binding to the cytoplasmic portion of the IFN receptor inhibiting phosphorylation of TYK2, STAT1, STAT2 impairing JAK STAT activation and therefore inhibiting specifically IFN-[alpha] mediated signalling (64).
All IFN[alpha]s and IFN[beta] bind to the same receptor and as a result, the cytoplasmic kinases JAK1 and TYK2 become activated and phosphorylate the STAT1 and STAT2 molecules.
Whereas autosomal-dominant hyperimmunoglobulin E syndrome is caused by mutations in STAT3, DOCK8 and TYK2 mutations are implicated in the comparatively rare autosomal-recessive forms of the disease.
JAK2 is a member of the Janus family of mammalian tyrosine kinases, which is comprised of four cytoplasmic tyrosine kinases : JAK1, JAK2, JAK3 and TYK2 (Imada and Leonard, 2000; Zhu et al.
In addition, Array continues to work on advancing two preclinical collaboration targets: TYK2 inhibitors for the treatment of inflammatory disease and PDGFR inhibitors for the treatment of fibrosis.
Celgene Research Programs - cFMS, TYK2, PDGFR: Celgene announced progress on three partnered research programs in April 2010 on which Array is conducting research: cFMS (oncology), TYK2 (inflammation) and PDGFR (fibrosis).
Celgene Research Programs - c-fms, TYK2, PDGFR: Celgene announced for the first time progress on three Array-partnered research programs during their research and development event on April 8, 2010: c-fms (oncology), TYK2 (inflammation) and PDGFR (inflammation).
XL019 is a potent inhibitor of JAK2 (IC50 = 2 nM), and is selective for JAK2 versus the other members of the JAK kinase family (JAK1 IC50 = 130 nM, JAK3 IC50 = 250 nM, TYK2 IC50 = 340 nM).
About JAK Inhibition and Baricitinib There are four known JAK enzymes: JAK1, JAK2, JAK3 and TYK2.