TXA2


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TXA2

abbreviation for thromboxane A2.

thromboxane A2

(throm-bok'san),

TXA2

An unstable compound synthesized in platelets and other cells from a prostaglandin, PGH2. It acts to aggregate platelets, is a potent vasoconstrictor, and mediates inflammation.
See: eicosanoid; prostaglandin; prostanoids

TXA2

thromboxane.
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This R value showed more dynamic range and sensitivity related to secondary platelet aggregation due to TXA2 release, causing a minor left shift in the [IC.
As a layer of platelets becomes activated on collagen, they recruit additional platelets via release of ADP and TXA2.
Although the level of thromboxane A2 (TXA2) was not assessed, deficit of inhibiting TXA2 synthesis was suspected to cause extensive vasospasm.
Moreover, EPA can change the concentration of arachidonic acid, which has a potential role in CV [79] and inhibit the synthesis of TXA2 [80].
Previous studies have shown that PPAR[gamma] ligands can suppress platelet activation and aggregation, and can reduce the release of TXA2, sCD40L, and ATP (Bodary et al.
l[alpha]], no direct effect of DDKA was observed, indicating that the antithrombotic action of DDKA may not be mediated via the arachidonic acid cascade, for PGI2 and TXA2 are products of arachidonic acid (AA) metabolism by cyclooxyge-nase (COX) (Tanaka et al.
Comparison of the antispastic and endothelium-protective features of papaverine, varapamil and glyceryl trinitrate Papaverine Verapamil GT (undiluted) OnsetF of effect + ++ +++ Duration of effect ++ +++ Spasm prevention + ++ - Spasm reversal + ++ +++ Block of receptor-mediated + - +++ contraction ([alpha]1, TXA2 receptor) Blockade of depolarizing ++ +++ ++ agent-mediated contraction (K+) pH of solution Acidic Neutral Protection of endothelium + +++ None or weak (-); medium (+); strong (++); extra strong (+++) GT- glyceryl trinitrate Table 2.
Effects of total saponins of Panax notoginseng on increasing PG12 in carotid artery and decreasing TXA2 in blood platelets.