TTF-1

TTF-1

A protein encoded by NKX2-1 on chromosome 14q13. TTF-1 is the term  preferred by pathologists for this protein; it is also widely used in immunohistochemistry for identifying thyroid or lung as sites of origin for tumours of unknown primary sites.
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2] In this case, the SRS was negative and the primary site could have been missed if a CT scan of the thorax and additional histological investigations, like a TTF-1, would not have been performed.
The panels have included TTF-1 with carcinoembryonic antigen for ACA and cytokeratin (CK) 5/6 and p63-desmoglein 3 (DG3) for SCC, (18-20) as well as TTF-1 and napsin A for ACA and p63 with CK5/6 for SCC.
These, in combination with some of the more traditional markers such as TTF-1, CK5 and p63, may enable much more confident identification of SqCC and LADC.
a privately held molecular diagnostics company focused on oncology, announced today results of a study that indicated that TTF-1, a commonly used cell-staining tumor pathology test, does not correctly identify half of non-small cell lung carcinoma (NSCLC) cases in patients that present with metastatic or poorly differentiated cancer.
Initially, the 8G7g3/1 clone of TTF-1 was reported to be positive in 76% of pulmonary adenocarcinomas.
It can be permanently mounted in a variety of mounting media and is suitable for both Iimmunohis-tochemistry and in-situ hybridization applications including HPV, CMV, EBV, p63, TTF-1, Ki-67, and other target antigens such as blood and lymphatic vessels, and basal and myoepithelial cells.
7530: Use of negative TTF-1 status to predict for negative EGFR mutations status with a high negative predictive value in patients with adenocarcinomas of the lung.
7) TTF-1 has been consistently expressed in sclerosing hemangioma in both the surface and the round stromal cells, (2-4) and was the key observation that first supported the idea that the cell of origin for both cellular components is a respiratory epithelial cell.
Although TTF-1 has historically been the most-specific marker for lung ACA, napsin A, a relatively new marker, has recently been shown (1) to be more sensitive and specific than TTF-1, especially when dealing with small cell carcinoma from various sites and was, therefore, included in our study.
Another lung-specific marker on the horizon is napsin A (Nap-A), which appears to complement TTF-1 in defining a primary lung carcinoma, (15) also appears to be helpful in subtyping NSCLC, and may be helpful in distinguishing NSCLC, particularly poorly differentiated adenocarcinoma, from SCC.