TERF1

(redirected from TRBF1)

TERF1

A gene on chromosome 8q21.11 that encodes a protein which is an integral component of the telomere nucleoprotein complex. It is present at telomeres throughout the cell cycle and inhibits telomerase, acting in cis to limit elongation of chromosome termini.
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p-53-dependent benzene-induced decrease or increase Decrease Adcy6, ApoE, AQ1, B cell antigen receptor, Cam III, CCR9, E2F1, WT: decreased FATP4, Fscn1, GPCR (EB11), Ig kappa light chain, IgA, IgH, p53-KO: unchanged mur42, Pdk1, PPT-B, Prkm1, TP, TRBF1 Increase Adipose fatty acid binding protein, Adh-3, caspase-11, cyclin G1, WT: increased CYP7B1, EGFB-3, emp-1, FKBP23, c-fos, Hox-4.