TRAF6


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TRAF6

A gene on chromosome 11p12 that encodes an E3 ubiquitin ligase which, together with UBE2N and UBE2V1, synthesises Lys-63-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. It also ubiquitinates a free/unanchored polyubiquitin chain, leading to MAP3K7 activation, and activates NF-kappaB and JUN. It may be essential for forming functional osteoclasts and is thought to play a role in dendritic cell maturation and/or activation. It represses c-Myb-mediated transactivation of B cells. It acts as an adapter protein for signal transduction by TNF receptor, as well as IL-1 and IL-17 receptors. It is expressed in the heart, brain, placenta, lungs, liver, skeletal muscle, kidneys and pancreas.
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2006) Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6.
Similar findings were also observed in this study, as higher TRAF6 expression was found in TG goats relative to RG goats.
7 cells, mouse leukemic monocyte macrophage cell line; RANKL, receptor activator of nuclear factor kappa-B ligand; RANK, receptor activator of nuclear factor [kappa] B; TRAP, tartrate-resistant acid phosphatase; EMSA, electrophoretic mobility shift assay; M-CSF, macrophage colony-stimulating factor; TRAF6, TNF receptor-associated factor 6; IRAK-1, interleukin 1 receptor associated kinase 1; TAK-1, transforming growth factor [beta] activated kinase; NIK, NF [kappa]B inhibitory kinases; IKK[alpha], activates I[kappa]B[alpha] kinase alpha; I[kappa]B[alpha], activates [kappa]B kinase beta; Phospho-IKK [alpha]/[beta], phospho activates I[kappa]B[alpha] kinase alpha/beta; I[kappa]B[alpha], inhibitory [kappa]alpha; DMEM, Dulbecco's modified Eagle medium; DCFH-DA, dichlorofluorescein diacetate.
In that situation, TRAF6 is very important in preventing premature differentiation so the satellite cells maintain their stemness.
Results of the current study showed that the expression levels of TLR9, MYD88, IRAK1, and TRAF6 in the PBMCs from CHB patients were significantly decreased in comparison with healthy controls.
To determine IRAK4 and TRAF6 molecules, the cytosolic fraction was subjected to electrophoresis in a 14% polyacrylamide gel (SDS-PAGE) and proteins transferred to nitrocellulose membranes.
TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology.
Polyphenol-rich propolis extracts from China and Brazil exert anti-inflammatory effects by modulating ubiquitination of TRAF6 during the activation of NF-kB," Journal of Functional Foods, vol.
Hindi and Ashok Kumar discovered that removing TRAF6 depletes Pax7, resulting in reduced muscle regeneration in both normal and Duchenne muscular dystrophy (DMD) mouse models.
41) EV71-induced miR-146a can suppress the expression of IRAK1 and TRAF6 which are two major elements in IFN production.
The RANKL receptor, RANK, lacks intrinsic enzymatic activity in its intracellular domain but it transduces signals by recruiting adapters, such as TRAF6, and leads to the activation of several signaling cascades (Takayanagi 2007).