TRAF6


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TRAF6

A gene on chromosome 11p12 that encodes an E3 ubiquitin ligase which, together with UBE2N and UBE2V1, synthesises Lys-63-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. It also ubiquitinates a free/unanchored polyubiquitin chain, leading to MAP3K7 activation, and activates NF-kappaB and JUN. It may be essential for forming functional osteoclasts and is thought to play a role in dendritic cell maturation and/or activation. It represses c-Myb-mediated transactivation of B cells. It acts as an adapter protein for signal transduction by TNF receptor, as well as IL-1 and IL-17 receptors. It is expressed in the heart, brain, placenta, lungs, liver, skeletal muscle, kidneys and pancreas.
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Results of the current study showed that the expression levels of TLR9, MYD88, IRAK1, and TRAF6 in the PBMCs from CHB patients were significantly decreased in comparison with healthy controls.
CIA increased TLR-4, TLR-2, MyD88 and TRAF6 mRNA expression and the related protein in the cartilage of arthritic joints.
Researchers already knew that a protein called TRAF6 is recruited to TLRs during the early phase of an immune response.