TRAF4

TRAF4

A gene on chromosome 17q11-q21.3 that encodes TNF receptor-associated factor 4, an adapter protein and signal transducer which links members of the tumour necrosis factor receptor (TNFR) family to various signalling pathways. TRAF4 plays a role in JNK activation, in NF-kappaB activation in response to Toll-like receptor signalling, and in regulating cell survival and apoptosis. It is required for normal skeletal and normal respiratory tract development, is required for RPS6KB1 activation in response to TNF signalling, and modulates TRAF6 activities.
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59-61) However, these deubiquitinating factors are not the only negative regulators of NODs; the latter include TRAF4 that binds directly to NOD2.
2011) A novel motif in the Crohn's disease susceptibility protein, NOD2, allows TRAF4 to down-regulate innate immune responses.
2012) IkappaB kinase alpha phosphorylation of TRAF4 downregulates innate immune signaling.
TGF-[beta] receptorTRAF4 interaction triggers Lys 63-linked TRAF4 polyubiquitylation and subsequent activation of the TGF-[beta]-activated kinase (TAK).
TRAF4 promotes TGF-beta receptor signaling and drives breast cancer metastasis.
393701 CSF2, TNF, FGFR3, SNCB, ALB, EEF1A2, NOS3, KIT, TRAF4 GOTERM_BP_FAT 9 0.
phox] phosphorylation and binding to TRAF4," Molecular and Cellular Biology, vol.