TRAF3


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TRAF3

A gene on chromosome 14q32.32 that encodes TNF receptor-associated factor 3, which regulates NF-kappaB kinase and MAP kinase activation, plays a central role in regulating B-cell survival, and is part of signalling pathways leading to cytokine and interferon production. TRAF3 is required for normal antibody isotype switching from IgM to IgG, and it plays a role in T-cell dependent immune responses as well as antiviral responses. It is an essential constituent of several E3 ubiquitin-protein ligase complexes and may promote Lys-63-linked ubiquitination of target proteins. It inhibits NF-kappaB activation in response to LTBR stimulation, as well as TRAF2-mediated NF-kappaB activation, and it downregulates proteolytic processing of NFKB2 and NF-kappaB activation. It promotes ubiquitination and proteasomal degradation of MAP3K14.
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pylori infection exhibited higher levels of Cdx2 expression and lower levels of TRAF3 expression than those of NOD1-intact mice.
2006) Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6.
Genetic defects or constant degradation of TRAF3 lead to the uncontrolled activity of what we call the noncanonical NF-kB pathway.
HSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: role for Sglutathionylation of TRAF3 and 6," PLoS Pathogens, vol.
The stimulation of TLR7 and TLR9 with their respective ligand results in the formation of a complex constituted by MyD88, IRAK-4, TRAF6, TRAF3, IRAK-1, IKK-[kappa], and IRF7 re sponsible for the activation of IRF7, which once phosphorylated is translocated to the nucleus and regulates the expression of type-I IFN.