TRAF2


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TRAF2

A gene on chromosome 9q34 that encodes TNF receptor-associated factor 2, an adapter molecule which regulates NF-kappaB and JNK activation and plays a role in regulating cell survival and apoptosis. TRAF2 is required for normal antibody isotype switching from IgM to IgG. It has E3 ubiquitin-protein ligase activity and promotes Lys-63-linked ubiquitination of target proteins (e.g., BIRC3, RIPK1 and TICAM1).
References in periodicals archive ?
We have previously reported that variant Y52C exerts a protective effect on Taiwanese PD through increasing stability of FBX07 protein and decreasing TRAF2 level (Chen et al.
After blocking, the blots were probed with FBX07 (1:1000 dilution, Abnova, Taipei, Taiwan), Flag (1:1000 dilution, Sigma), TRAF2 (1:1000 dilution, Santa Cruz Biotechnology, Santa Cruz, CA, USA), GATA1 (1:1000 dilution.
Medicinal herbs enhancing GATA2 expression to modulate FBX07 and TRAF2 abundance
Through binding and mediating ubiquitin conjugation, FBX07 has been shown to negatively regulate TRAF2 abundance (Chen et al.
Previously, we also showed that FBX07 variant resulting in increased protein stability and reduced TRAF2 may contribute to the reduced PD susceptibility (Chen et al.
Liu, "The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation," Immunity, vol.
Kang, "Roles of TRAF2 and TRAF3 in Epstein-Barr virus latent membrane protein 1-induced alternative NF-[kappa]B activation," Virus Genes, vol.