TRAF1


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TRAF1

A gene on chromosome 9q33-q34 that encodes TNF-receptor-associated factor 1, an adapter molecule which regulates NF-kappaB and JNK activation and plays a role in regulating cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that ubiquitinates target proteins, such as MAP3K14, and recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.
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Diagnostic and prognostic evaluation of phenotypic markers TRAF1, MUM1, BCL2 and CD15 in cutaneous CD30-positive lymphoproliferative disorders.
Differential expression of TRAF1 aids in the distinction of cutaneous CD30-positive lymphoproliferations.
From a functional perspective, it is interesting that TRAF1 is likely involved in TNF signaling, and we are looking to identify the role it may play in predicting the efficacy of drugs that work via this pathway.
Inhibition of IKK correlated with suppression of NF-kB dependent genes that prevent apoptosis (IAP2, cFLIP, TRAF1, survivin, and bcl- 2), promote proliferation (cyclin D1, COX-2, and c-myc), and promote angiogenesis (VEGF and MMP-9).
NF-[kappa]B antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and cIAP2 to suppress caspase-8 activation.