TRAF1


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TRAF1

A gene on chromosome 9q33-q34 that encodes TNF-receptor-associated factor 1, an adapter molecule which regulates NF-kappaB and JNK activation and plays a role in regulating cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that ubiquitinates target proteins, such as MAP3K14, and recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.
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Key findings of this study included the upregulation of the IRF1, IL-6 and the TNF adapter protein TNFSF10 as well as the TNF receptor family members TRADD and TRAF1 and the other known inflammation-related transcripts such as PTGS2, BCL2, and CCND1 on LPS stimulation.
NF-[kappa]B antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and cIAP2 to suppress caspase-8 activation.
Characterization of LMP-1's association with TRAF1, TRAF2, and TRAF3.
96,156) Approximately 65% to 80% of C-ALCLs, LyPs, transformed MFs, and cases of secondary skin involvement in systemic ALK- ALCL express TRAF1 and 70% to 100% express MUM1; therefore, these antigens have limited usefulness in distinguishing CALCL from LyP or systemic disease.