TRAF1


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TRAF1

A gene on chromosome 9q33-q34 that encodes TNF-receptor-associated factor 1, an adapter molecule which regulates NF-kappaB and JNK activation and plays a role in regulating cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that ubiquitinates target proteins, such as MAP3K14, and recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.
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Key findings of this study included the upregulation of the IRF1, IL-6 and the TNF adapter protein TNFSF10 as well as the TNF receptor family members TRADD and TRAF1 and the other known inflammation-related transcripts such as PTGS2, BCL2, and CCND1 on LPS stimulation.
From a functional perspective, it is interesting that TRAF1 is likely involved in TNF signaling, and we are looking to identify the role it may play in predicting the efficacy of drugs that work via this pathway.
NF-[kappa]B antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and cIAP2 to suppress caspase-8 activation.
Characterization of LMP-1's association with TRAF1, TRAF2, and TRAF3.
96,156) Approximately 65% to 80% of C-ALCLs, LyPs, transformed MFs, and cases of secondary skin involvement in systemic ALK- ALCL express TRAF1 and 70% to 100% express MUM1; therefore, these antigens have limited usefulness in distinguishing CALCL from LyP or systemic disease.