TMPRSS2

TMPRSS2

A gene on chromosome 21q22.2 that encodes an androgen-regulated transmembrane serine protease, the translocation of which to either ERG (at 21q22.3) or ETV1 (at 7p21.2) (both of which belong to the ETS transcription factor family) provides a selective mechanism for prostatic cancer initiation or, more likely, maintenance. It is strongly expressed in the small intestine.
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Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages independent of TMPRSS2 expression.
Comprehensive assessment of TMPRSS2 and ETS family gene aberrations in clinically localized prostate cancer.
Changes in the distribution of type II transmembrane serine protease, TMPRSS2 and in paracellular permeability in IPEC-J2 cells exposed to oxidative stress," Inflammation, vol.
As outlined in this review, the knowledge gained within the last decades and the experience gained from the pandemic influenza A (H1N1) 2009 and HPAI outbreak greatly improved our understanding of the role of host cellular factors in the pathogenicity of IAV infection: (i) Several cell surface anchored trypsin-like serine proteases are candidates of HA-processing protease for seasonal human IAV, TMPRSS2, HAT and TMPRSS4, other than secreted HA-processing proteases in the airway, such as tryptase Clara, trypsin and mini-plasmin, and for HPAI viruses MSPL/ TMPRSS13 other than furin and PCs.
The spike-protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies.
Gnirss K, Kuhl A, Karsten C, Glowacka I, Bertram S, Kaup F, Hofmann H, Pohlmann S (2012) Cathepsins B and L1 activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages independent of TMPRSS2 expression.
About half of prostate cancers exhibit fusion of the androgen-regulated TMPRSS2 gene and the ERG oncogene.
The test, which is not available commercially, detects fusions between TMPRSS2 (T2), an androgen-responsive gene, and the oncogenic transcription factor ERG.
2005) Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.
The measurement of the fusion of TMPRSS2 to ERG helps to identify prostate cancer aggressiveness and also the personalization of treatment options (Park et al.