TEK

(redirected from TIE2)
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TEK

A gene on chromosome 9p21 that encodes a transmembrane tyrosine protein kinase that forms a heterodimer with TIE1, modulating its activity. TEK acts as a receptor for ANGPT1, ANGPT2 and ANGPT4, regulating angiogenesis; endothelial cell survival, proliferation, migration, adhesion and cell spreading; reorganisation of the actin cytoskeleton; and, depending on context, maintenance of vascular quiescence. TEK has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels into interstitial tissue. It is required for normal angiogenesis and heart development during embryogenesis, and it is required for postnatal haematopoiesis.
References in periodicals archive ?
The chemical library was run against these assays, as was a repeat of the TIE2 assayfrom the original data series (Table 2).
Placental vascular remodeling was suppressed in rats after exposure to the developmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and was significantly correlated with decreased expression of TIE2 mRNA (Ishimura et al.
165], KDR, ANGPT1, ANGPT2, TIE1 and TIE2 were investigated.
Furthermore, the vascular growth factor receptors TIE1 and TIE2 are rapidly down-regulated in response to [E.
In preclinical studies, BAY 73-4506 has been shown to inhibit tumor growth by hitting targets along a spectrum of angiogenic pathways, including VEGFR and TIE2.
BAY 73-4506 has been shown to inhibit tumor growth in preclinical models by hitting targets along a spectrum of angiogenic pathways, including VEGFR and TIE2.