IL10

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IL10

A gene on chromosome 1q31-q32 that encodes interleukin-10, a cytokine produced primarily by monocytes, but also by lymphocytes, which inhibits the synthesis of a number of cytokines (including IFN-gamma, IL-2, IL-3, TNF and GM-CSF) produced by activated macrophages and helper T cells. IL10 has pleiotropic effects in immunoregulation and inflammation. It downregulates expression of Th1 cytokines, MHC class-II antigens and co-stimulatory molecules on macrophages, and it enhances B cell survival, proliferation and antibody production. It can block NF-kappa B activity, and is involved in regulating the JAK-STAT signalling pathway.

Molecular pathology
IL10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
References in periodicals archive ?
Rohan Jetley, promoter TGIF, who helped put the event together agreed, " Generally we organise fashion events or music nights, this time we thought we would do something different.
December 19(th) - TGIF at the Pawbar/ Thank God it's Food
Kamran Jafar, Group Head JS Bank said at the occasion "We firmly believe in enriching the lives of our customers through our World of Privileges program, and this alliance with Pizza Hut, Burger King and TGIF is another spectacular way for our customers to enjoy the privileges we offer as a Bank.
This asset's prime location on the Route 110 Corridor and tenant base, along with the fixed increases in the TGIF lease was attractive to the buyer.
This book/CD-ROM resource for teachers of grades 6-12 contains about 200 classroom instructional strategies, plus a guide to effective lesson design following the TGIF model of teacher-directed instruction, guided practice activities, independent practice activities, and final measurement.
Indians comprised 80 per cent of those who came to TGIF.
So we're moving that TGIF meeting to Thursday, so that people in Asia can get it during their work week.
The Riese family has been using this formula for many years, and now owns or controls properties located in some of the most highly trafficked locations in the city, including the TGIF Fridays building in Times Square at Broadway and 46 St.
Sergey and Larry's laid back but business-savvy way of doing things even extended to TGIF (Thank God It's Friday) meetings held in the staff car park - over games of roller-hockey.
Instead of spending cash gifts from their bar and bat mitzvahs, 28 Jewish students from Solomon Schechter Academy in Dallas created the TGIF (To Give in Friendship) Fund to donate the money to charitable causes, especially those that serve children.
THANK GOD they didn't check our age at TGIF before they served us our drinks.
Wayne Towne Center is home to prominent national tenants, including Fortunoff, JC Penny, Borders, Loehmans, TGIF and Daffy's.