IL10

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IL10

A gene on chromosome 1q31-q32 that encodes interleukin-10, a cytokine produced primarily by monocytes, but also by lymphocytes, which inhibits the synthesis of a number of cytokines (including IFN-gamma, IL-2, IL-3, TNF and GM-CSF) produced by activated macrophages and helper T cells. IL10 has pleiotropic effects in immunoregulation and inflammation. It downregulates expression of Th1 cytokines, MHC class-II antigens and co-stimulatory molecules on macrophages, and it enhances B cell survival, proliferation and antibody production. It can block NF-kappa B activity, and is involved in regulating the JAK-STAT signalling pathway.

Molecular pathology
IL10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
References in periodicals archive ?
Saxophonist Alto Reed, founding and current member of "Bob Seger and the Silver Bullet Band," along with TGIF Entertainment Group, have assembled a star studded roster of Detroit grown talent, including legendary Mitch Ryder, teamed with surprise guest appearances of nationally known talent.
In London, TGIF means the 100-plus staff shutting down their computers early and cracking open a few beers while being entertained by musically-minded colleagues.
December 19(th) - TGIF at the Pawbar/ Thank God it's Food
Basant Lok will no longer be the same, for TGIF will now only be at DLF Place malls.
Wayne Towne Center is home to prominent national tenants, including Fortunoff, JC Penny, Borders, Loehmans, TGIF and Daffy's.
Cooper" originally aired from 1992-1997, joining ABC's famous TGIF block in its second season, and winning two awards in 1993: Top TV Series from the American Society of Composers, Authors and Publishers, and Broadcast Music, Inc.
Don't think: ABC's TGIF must stand for ``Thank Goodness It's Facile.
Playtex(R) Intimates, is a leading intimate apparel brand with a broad portfolio of bras, panties and shapewear, including TGIF and the legendary 18 Hour(R) and Cross Your Heart(R) lines.
Local neighbors of River Birch Shopping Center include Kohl's, Lowe's Home Improvement Warehouse, Pathmark, Regal Cinemas, Sears Hardware, Shop Rite, TGIF and TJ Maxx.
Why do Spice Girls have TGIF written on their shoes?
The Radisson Hotel & Suites Austin and its signature TGIF restaurant are located at First and Congress along the shores of Town Lake next to the hike and bike trail and within walking distance to businesses, the Convention Center, Austin's Warehouse and 6th Street Entertainment District and other points of interest.
January 9, 16, 23 & 30: TGIF meets every Friday in a bar or restaurant in Basel from 18:30-20:30