TGFbeta

TGFβ

TGFB1

A gene on chromosome 19q13.1 that encodes a member of the transforming growth factor beta (TGFB) family of cytokines. These multifunctional peptides up- and downregulate proliferation, differentiation, adhesion, migration, death and other functions in many cell types. Active TGFB1 is either homodimeric or heterodimeric with other TGFB family members.

Molecular pathology
TGFB1 mutations cause Camurati-Engelmann disease; TGFB1 is often upregulated in tumour cells.
References in periodicals archive ?
Relationships between TGFbeta proteins and oxygen concentrations inside the first trimester human gestational sac.
TGFbeta can stimu late the p(38)/beta-catenin/PPARgamma signaling pathway to promote the EMT, invasion and migration of non-small cell lung cancer (H460 cells).
TGFbeta signalling: a complex web in cancer progression.
Dietary chlorophyllin abrogates TGFbeta signaling to modulate the hallmark capabilities of cancer in an animal model of forestomach carcinogenesis.
Novartis said in a statement that these transactions add Admune's IL15 agonist program, Palobiofarma's adenosine receptor and Xoma's TGFbeta inhibition programs to its own immuno-oncology portfolio.
TGFbeta loss activates ADAMTS-1-mediated EGF-dependent invasion in a model of esophageal cell invasion.
The researchers think that reducing IRF-5 levels sets off a chain of events, starting with increased TGFbeta levels.
Asthama--Polymorphisam (Normal variation) in particular genes may decrease the risk of severe dengue complications like TNF Alpha, Mannan--Binding protein, CTLA4, TGFBeta, DC-SIGN, G6PD deficiency individual are at high risk.
Endoglin, a TGFbeta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1.
Algunos genes involucrados en la morfogenesis craneofacial son: senales polarizantes (SHH,BP2,BMP4,BMP7; Smad 2-4), factores de crecimiento receptores (EGF,EGFR,TGF- alfa, TGFbeta 1-3,FGF1, FGF2, FGF8), factores de transcripcion (AP2-alfa, DLX 1-6, Gli 2 -3, PITX1, PITX2, PRX1, HOXA2, LRF6, LHX8,PAX9,MSX1,TBX1,TBX22), moleculas de adhesion celular (PBRL1, Conexin 43, E-Cadherina), matriz extracelular (COL2A1, COL11A1, COL11A2, MMP2, MMP3, MMP9, MMP13, MP1-3, fibronectina).
Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression.